Neurology Department, Desgenettes Military Teaching Hospital, 108, boulevard Pinel, 69275 Lyon cedex 3, France.
Orthop Traumatol Surg Res. 2009 Dec;95(8):639-44. doi: 10.1016/j.otsr.2009.09.009.
Hyperthermic isolated limb perfusion (ILP) (2 mg, TNF-alpha and 100mg, melphalan) was performed for an irresectable right thigh desmoid tumor with calf extension in a 49-year-old man. The patient had a history of four resections since the age of 19 years. Local ILP toxicity appeared with extensive edema and common peroneal neurologic impairment including paresis that remained severe 10 months later. One of the most troublesome side effects of perfusion is peripheral nerve damage, which has been reported at a rate of between 1 and 48% of perfused patients. ILP is an effective treatment in recurrence situations or where resection threatens loss of function; it, however, requires administration in specialized centers, progress in standardization and close monitoring to avoid locoregional toxicity, the mechanisms of which merit further investigation. Emergency compartmental pressure measurement may indicate fasciotomy, can be of great interest.
高热隔离肢体灌注（ILP）（2mg，TNF-α和 100mg，美法仑）用于治疗一名 49 岁男性无法切除的右大腿硬纤维瘤伴小腿延伸。该患者自 19 岁以来已进行了四次切除手术。局部 ILP 毒性表现为广泛水肿和腓总神经功能障碍，包括 10 个月后仍严重的瘫痪。灌注最麻烦的副作用之一是周围神经损伤，据报道，灌注患者中有 1%至 48%发生这种损伤。ILP 是复发情况下或切除威胁功能丧失时的有效治疗方法；然而，它需要在专门的中心进行管理，需要进行标准化的进展和密切监测，以避免局部区域毒性，其机制值得进一步研究。紧急间隔压测量可能表明需要筋膜切开术，这可能非常有意义。
