Department of Psychiatry, Columbia University, New York, NY 10032, USA.
Neurobiol Dis. 2010 Mar;37(3):534-41. doi: 10.1016/j.nbd.2009.11.016. Epub 2009 Nov 26.
Lyme disease, caused by the bacterium Borrelia burgdorferi, can cause multi-systemic signs and symptoms, including peripheral and central nervous system disease. This review examines the evidence for and mechanisms of inflammation in neurologic Lyme disease, with a specific focus on the central nervous system, drawing upon human studies and controlled research with experimentally infected rhesus monkeys. Directions for future human research are suggested that may help to clarify the role of inflammation as a mediator of the chronic persistent symptoms experienced by some patients despite antibiotic treatment for neurologic Lyme disease.
莱姆病是由伯氏疏螺旋体引起的，可引起多系统的体征和症状，包括周围和中枢神经系统疾病。本综述检查了神经莱姆病炎症的证据和机制，特别关注中枢神经系统，参考了人类研究和用实验感染恒河猴进行的对照研究。提出了未来的人类研究方向，这可能有助于阐明炎症作为一种介质在一些患者中发挥作用，尽管他们已经接受了抗生素治疗神经莱姆病，但仍会持续出现慢性症状。
