Kinderlehrer Daniel A
Private Practice, Denver, CO, USA.
Int Med Case Rep J. 2023 Mar 3;16:109-115. doi: 10.2147/IMCRJ.S395342. eCollection 2023.
Lyme disease can result in severe neuropsychiatric symptoms that may be resistant to treatment. The pathogenesis of neuropsychiatric Lyme disease is associated with autoimmune induced neuroinflammation. This case report describes an immunocompetent male with serologically positive neuropsychiatric Lyme disease who did not tolerate antimicrobial or psychotropic medications and whose symptoms remitted when he began psilocybin in microdosed (sub-hallucinogenic) amounts. A literature review of its therapeutic benefits reveals that psilocybin is both serotonergic and anti-inflammatory and therefore may offer significant therapeutic benefits to patients with mental illness secondary to autoimmune inflammation. The role of microdosed psilocybin in the treatment of neuropsychiatric Lyme disease and autoimmune encephalopathies warrants further study.
莱姆病可导致严重的神经精神症状，这些症状可能对治疗有抵抗性。神经精神性莱姆病的发病机制与自身免疫性诱导的神经炎症有关。本病例报告描述了一名免疫功能正常的男性，其血清学检测显示神经精神性莱姆病呈阳性，他无法耐受抗菌药物或精神药物，而当他开始服用微剂量（低于致幻剂量）的裸盖菇素时，症状得到缓解。对其治疗益处的文献综述表明，裸盖菇素具有血清素能和抗炎作用，因此可能为继发于自身免疫性炎症的精神疾病患者提供显著的治疗益处。微剂量裸盖菇素在神经精神性莱姆病和自身免疫性脑病治疗中的作用值得进一步研究。
