Kane Ari, Yang Isaac
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA.
Neurosurg Clin N Am. 2010 Jan;21(1):77-86. doi: 10.1016/j.nec.2009.08.011.
Interferon-gamma (IFNgamma) is a cytokine that acts on cell-surface receptors, activating transcription of genes that offer treatment potential by increasing tumor immunogenicity, disrupting proliferative mechanisms, and inhibiting tumor angiogenesis. However, abnormally low levels of IFNgamma are produced by tumor cells and local T cells in the glioma microenvironment. Current investigations into the immunomodulating effects of IFNgamma suggest that IFNgamma has the potential to be used clinically in the treatment of brain tumors and as a promising adjunct to other immunotherapeutic modalities. Here the authors review the published literature that highlights the potential role of IFNgamma in the treatment and immunotherapy of malignant gliomas.
γ干扰素（IFNγ）是一种作用于细胞表面受体的细胞因子，它通过增加肿瘤免疫原性、破坏增殖机制和抑制肿瘤血管生成来激活具有治疗潜力的基因转录。然而，在胶质瘤微环境中，肿瘤细胞和局部T细胞产生的IFNγ水平异常低。目前对IFNγ免疫调节作用的研究表明，IFNγ有潜力在临床上用于治疗脑肿瘤，并作为其他免疫治疗方式的有前景的辅助手段。本文作者回顾了已发表的文献，这些文献突出了IFNγ在恶性胶质瘤治疗和免疫治疗中的潜在作用。
