1 Department of Neurosurgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, People's Republic of China.
2 Fujian Neurosurgical Institute, Fuzhou, Fujian, People's Republic of China.
Integr Cancer Ther. 2018 Sep;17(3):674-683. doi: 10.1177/1534735418762537. Epub 2018 Apr 2.
Malignant gliomas are the most common brain tumors with high rates of recurrence and mortality. Novel approaches are in research, and immunotherapy emerges as a promising strategy. Recently, scientific attention has been focused on Ganoderma lucidum polysaccharides (GL-PS), one of the critical bioactive components of G lucidum, which have been recognized as a promising natural source of immunomodulatory and anticancer compounds. It remains unknown whether the GL-PS have any immunomodulatory and anticancer effects on brain glioma. This study was designed to identify and characterize the antitumor action and influence of immune system of GL-PS in glioma-bearing rats. Results showed that GL-PS increased the concentration of serum interleukin-2, tumor necrosis factor-α, and interferon-γ, and enhanced the cytotoxic activity of natural killer cells and T cells, promoting the functional maturation of dendritic cells, thus resulting in the inhibition of glioma growth and prolonged survival of rats. Therefore, GL-PS may be potentially useful as part of the treatment regimen to regulate host immune responses and increase the antitumor effects of immunotherapy for glioma.
恶性胶质瘤是最常见的脑肿瘤，具有高复发率和死亡率。目前正在研究新的方法，免疫疗法作为一种有前途的策略出现了。最近，科学研究的焦点集中在灵芝多糖（GL-PS）上，它是灵芝的关键生物活性成分之一，被认为是一种有前途的免疫调节和抗癌化合物的天然来源。目前尚不清楚 GL-PS 是否对脑胶质瘤有任何免疫调节和抗癌作用。本研究旨在鉴定和表征 GL-PS 在荷脑胶质瘤大鼠中的抗肿瘤作用和免疫系统的影响。结果表明，GL-PS 增加了血清白细胞介素-2、肿瘤坏死因子-α和干扰素-γ的浓度，增强了自然杀伤细胞和 T 细胞的细胞毒性活性，促进了树突状细胞的功能成熟，从而抑制了胶质瘤的生长，延长了荷瘤大鼠的存活时间。因此，GL-PS 可能作为治疗方案的一部分，用于调节宿主免疫反应，增加免疫疗法对脑胶质瘤的抗肿瘤作用。
