免疫疗法联合化疗治疗肿瘤。

Immunotherapy combined with chemotherapy in the treatment of tumors.

作者信息

Frazier James L, Han James E, Lim Michael, Olivi Alessandro

机构信息

Department of Neurosurgery, The Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, 600 North Wolfe Street, Phipps 100, Baltimore, MD 21224, USA.

出版信息

Neurosurg Clin N Am. 2010 Jan;21(1):187-94. doi: 10.1016/j.nec.2009.09.003.

DOI:10.1016/j.nec.2009.09.003

PMID:19944977

Abstract

This article provides a broad overview of the data, including laboratory and clinical studies, currently available on the combination of immunotherapy and chemotherapy for treating cancer. The various forms of immunotherapy combined with chemotherapy include monoclonal antibodies, adoptive lymphocyte transfer, or active specific immunotherapy, such as tumor proteins, irradiated tumor cells, tumor cell lysates, dendritic cells pulsed with peptides or lysates, or tumor antigens expressed in plasmids or viral vectors. This discussion is not limited to malignant brain tumors, because many of the studies have been conducted on various cancer types, thereby providing a comprehensive perspective that may encourage further studies that combine chemotherapy and immunotherapy for treating brain tumors.

摘要

本文全面概述了目前可获得的关于免疫疗法与化疗联合治疗癌症的数据，包括实验室研究和临床研究。与化疗联合的各种免疫疗法形式包括单克隆抗体、过继性淋巴细胞转移或主动特异性免疫疗法，如肿瘤蛋白、辐照肿瘤细胞、肿瘤细胞裂解物、用肽或裂解物脉冲处理的树突状细胞，或在质粒或病毒载体中表达的肿瘤抗原。本讨论不限于恶性脑肿瘤，因为许多研究是针对各种癌症类型进行的，从而提供了一个全面的视角，可能会鼓励进一步开展联合化疗和免疫疗法治疗脑肿瘤的研究。