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一些新型苯并[b]噻吩衍生物的合成、表征及生物活性研究

Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives.

机构信息

Department of Chemistry, National Institute of Technology-Karnataka, Surathkal, Mangalore 575 025, India.

出版信息

Eur J Med Chem. 2010 Feb;45(2):825-30. doi: 10.1016/j.ejmech.2009.11.015. Epub 2009 Nov 11.

Abstract

Benzo[b]thiophene molecules are found to be important tools in synthetic medicinal chemistry. They are of current interest due to their wide spectrum of pharmacological properties. In view of the biological activities of benzo[b]thiophene containing molecules, in this present research work, we propose the synthesis of some new benzo[b]thiophene derivatives such as thiadiazoles, oxadiazoles, pyrazolin & diaryl pyrazoles starting from 3-chlorobenzo[b]thiophene-2-carboxyl chloride. These newly synthesized compounds were characterized by elemental analyses, I.R, NMR and Mass spectral studies. Some of the selected compounds were screened for their antibacterial, antifungal and anti-inflammatory studies. Many of the molecules were found to be potent.

摘要

苯并[b]噻吩分子被发现是合成药物化学中的重要工具。由于其广泛的药理特性,它们目前受到关注。鉴于含苯并[b]噻吩分子的生物活性,在本研究工作中,我们提出了从 3-氯苯并[b]噻吩-2-羧酸氯开始合成一些新的苯并[b]噻吩衍生物,如噻二唑、恶二唑、吡唑啉和二芳基吡唑。这些新合成的化合物通过元素分析、红外光谱、核磁共振和质谱研究进行了表征。对一些选定的化合物进行了抗菌、抗真菌和抗炎研究。许多分子被发现具有很强的活性。

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