Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil.
Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife 50740-520, PE, Brazil.
Mar Drugs. 2022 Jan 26;20(2):103. doi: 10.3390/md20020103.
In this study, films of chitosan and 2-amino-4,5,6,7-tetrahydrobenzo[]thiophene-3-carbonitrile (6CN), a 2-aminothiophene derivative with great pharmacological potential, were prepared as a system for a topical formulation. 6CN-chitosan films were characterized by physicochemical analyses, such as Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and scanning electronic microscopy (SEM). Additionally, the antifungal potential of the films was evaluated in vitro against three species of (, , and ). The results of the FTIR and thermal analysis showed the incorporation of 6CN in the polymer matrix. In the diffractogram, the 6CN-chitosan films exhibited diffraction halos that were characteristic of amorphous structures, while the micrographs showed that 6CN particles were dispersed in the chitosan matrix, exhibiting pores and cracks on the film surface. In addition, the results of antifungal investigation demonstrated that 6CN-chitosan films were effective against species showing potential for application as a new antifungal drug.
在这项研究中，制备了壳聚糖和 2-氨基-4,5,6,7-四氢苯并[B]噻吩-3-甲腈（6CN）的薄膜，6CN 是一种具有巨大药理学潜力的 2-氨基噻吩衍生物，作为局部制剂系统。通过傅里叶变换红外光谱（FTIR）、差示扫描量热法（DSC）、热重分析（TGA）、X 射线衍射（XRD）和扫描电子显微镜（SEM）等物理化学分析对 6CN-壳聚糖薄膜进行了表征。此外，还评估了薄膜对三种（、和）的体外抗真菌潜力。FTIR 和热分析的结果表明 6CN 掺入聚合物基质中。在衍射图谱中，6CN-壳聚糖薄膜显示出特征为无定形结构的衍射晕，而微观照片显示 6CN 颗粒分散在壳聚糖基质中，薄膜表面呈现出孔隙和裂缝。此外，抗真菌研究的结果表明，6CN-壳聚糖薄膜对 种具有抗真菌作用，显示出作为新型抗真菌药物的应用潜力。
