Joint Bone Spine. 2009 Dec;76(6):581-3. doi: 10.1016/j.jbspin.2009.04.007.
Vasculogenesis is the generation of vessels from endothelial progenitor cells (EPCs). Attenuated numbers and function of EPCs associated with defective vasculogenesis are present in rheumatoid arthritis (RA), scleroderma and other autoimmune-inflammatory diseases, which have significant relevance for increased cardio- and cerebrovascular morbidity and mortality in arthritis [–5]. Stimulation of EPCs and vasculogenesis may be beneficial to prevent and manage atherosclerosis related to arthritis. [–5].
血管发生是指从内皮祖细胞（EPCs）生成血管。类风湿关节炎（RA）、硬皮病和其他自身免疫性炎症性疾病中，EPCs 的数量和功能减弱，与血管发生缺陷有关，这与关节炎患者心血管和脑血管发病率和死亡率增加有显著相关性[3-5]。刺激 EPCs 和血管发生可能有助于预防和治疗与关节炎相关的动脉粥样硬化[3-5]。
