Wang Jun, Fivecoat Hayley, Ho Lap, Pan Yong, Ling Emi, Pasinetti Giulio Maria
Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer's Disease, Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Biochim Biophys Acta. 2010 Aug;1804(8):1690-4. doi: 10.1016/j.bbapap.2009.11.015. Epub 2009 Nov 26.
Sirt1, a mammalian member of the sirtuin gene family, holds great potential for promoting longevity, preventing against disease and increasing cell survival. For example, studies suggest that the beneficial impact of caloric restriction in promoting longevity and cellular function may be mediated, in part, by Sirt1 through mechanisms involving PGC-1alpha, which plays important role in the regulation of cellular metabolism and inflammatory and antioxidant responses. Sirt1 may also interfere with mechanisms implicated in pathological disorders. We will present recent evidence indicating that Sirt1 may protect against Alzheimer's disease by interfering with the generation of beta-amyloid peptides. We will discuss Sirt1 as a potential novel target, in addition to the development of Sirt1 activators for the prevention and treatment of Alzheimer's disease.
沉默调节蛋白1（Sirt1）是沉默调节蛋白基因家族的哺乳动物成员，在促进长寿、预防疾病和提高细胞存活率方面具有巨大潜力。例如，研究表明，热量限制在促进长寿和细胞功能方面的有益影响可能部分由Sirt1通过涉及过氧化物酶体增殖物激活受体γ共激活因子1α（PGC-1α）的机制介导，PGC-1α在细胞代谢以及炎症和抗氧化反应的调节中发挥重要作用。Sirt1也可能干扰与病理紊乱相关的机制。我们将展示最近的证据，表明Sirt1可能通过干扰β-淀粉样肽的生成来预防阿尔茨海默病。除了开发用于预防和治疗阿尔茨海默病的Sirt1激活剂外，我们还将讨论Sirt1作为一个潜在的新靶点。
