The Department of Endocrinology, Jiangsu Province Hospital of TCM, Nanjing, China.
Diabetes Res Clin Pract. 2010 Feb;87(2):157-60. doi: 10.1016/j.diabres.2009.11.002. Epub 2009 Nov 28.
The interaction of advanced glycation end products (AGEs) and the receptor for advanced glycation end products (RAGE) has played an important role in the pathogenesis of diabetic nephropathy. In the present study, we measured the relationship of plasma soluble isoform of RAGE (sRAGE) and urinary microalbumin excretion in the early stage of type 2 diabetic nephropathy.
180 patients with early stage of type 2 diabetic nephropathy were recruited into the study. Plasma sRAGE and the characterized AGE carboxymethyllysine (CML) were measured by enzyme-linked immunosorbent assay.
Plasma sRAGE positively correlated with the level of CML (R=0.22, P=0.03) while sRAGE was not significantly correlated with the urinary mAlb/Cr (R=0.15, P=NS). On stepwise linear regression analysis, AGE and GFR were the main independent determinants of plasma sRAGE concentration.
Plasma sRAGE is not significantly associated with urinary microalbumin excretion in the early stage of diabetic nephropathy while it is correlated positively with circulating AGE and negatively with glomerular filtration rate (GFR).
晚期糖基化终产物（AGE）与其受体（RAGE）的相互作用在糖尿病肾病的发病机制中起重要作用。本研究旨在测定 2 型糖尿病肾病早期患者血浆可溶性 RAGE（sRAGE）与尿微量白蛋白排泄率的关系。
本研究纳入了 180 例 2 型糖尿病肾病早期患者，采用酶联免疫吸附法测定血浆 sRAGE 和特征性 AGE 羧甲基赖氨酸（CML）的水平。
血浆 sRAGE 与 CML 水平呈正相关（R=0.22，P=0.03），而 sRAGE 与尿 mAlb/Cr 无明显相关性（R=0.15，P=NS）。逐步线性回归分析显示，AGE 和肾小球滤过率（GFR）是血浆 sRAGE 浓度的主要独立决定因素。
在糖尿病肾病早期，血浆 sRAGE 与尿微量白蛋白排泄率无明显相关性，而与循环 AGE 呈正相关，与肾小球滤过率（GFR）呈负相关。
