a Department of Endocrinology , Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine , Nanjing , Jiangsu , China.
b Department of Otorhinolaryngology , Affiliated Hospital of Qingdao University , Qingdao , Shandong , China.
Ren Fail. 2017 Nov;39(1):698-701. doi: 10.1080/0886022X.2017.1384391.
To explore the possible correlations between plasma heparanase and albuminuria, glucose and lipid metabolism in the type 2 diabetic nephropathy patients at the early stage.
One hundred and forty patients with type 2 diabetic nephropathy at early stage were recruited into the study. Plasma heparanase and the characterized advanced glycation end products (AGEs), carboxymethyllysine (CML) were measured by enzyme-linked immunosorbent assay.
Plasma heparanase was positively associated with fasting blood glucose (R = 0.24, p = .01) while heparanase was not significantly correlated with the urinary microalbumin to creatinine ratio (urinary mAlb/Cr) (R = 0.05, p = .58) and CML (R = 0.16, p = .26). On stepwise linear regression analysis, fasting blood glucose was the main independent determinants of plasma heparanase concentration.
Plasma heparanase is not significantly associated with urinary mAlb/Cr while it is correlated positively with blood glucose levels in the early stage of diabetic nephropathy. Plasma heparnase might be regarded as a marker for vascular endothelial cells injury in diabetic patients.
探讨 2 型糖尿病肾病早期患者血浆乙酰肝素酶与白蛋白尿、糖脂代谢之间的可能相关性。
选取 140 例 2 型糖尿病肾病早期患者作为研究对象，采用酶联免疫吸附法检测血浆乙酰肝素酶和特征性晚期糖基化终产物（AGEs）羧甲基赖氨酸（CML）。
血浆乙酰肝素酶与空腹血糖呈正相关（R=0.24，p=0.01），而与尿微量白蛋白与肌酐比值（urinary mAlb/Cr）（R=0.05，p=0.58）和 CML（R=0.16，p=0.26）无明显相关性。逐步线性回归分析显示，空腹血糖是血浆乙酰肝素酶浓度的主要独立决定因素。
在 2 型糖尿病肾病早期，血浆乙酰肝素酶与尿 mAlb/Cr 无明显相关性，而与血糖水平呈正相关。血浆乙酰肝素酶可能被视为糖尿病患者血管内皮细胞损伤的标志物。
