Global Discovery Chemistry/Oncology and Exploratory Chemistry, Novartis Institutes for Biomedical Research, 5400 Hollis Street, Emeryville, CA 94608, USA.
Bioorg Med Chem Lett. 2010 Jan 1;20(1):157-60. doi: 10.1016/j.bmcl.2009.11.012. Epub 2009 Nov 12.
A series of tetrahydro-beta-carbolines were identified by HTS as inhibitors of the kinesin Eg5. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus of removing potential metabolic liabilities and improving cellular potency.
通过高通量筛选，鉴定出一系列四氢-β-咔啉类化合物为驱动蛋白 Eg5 的抑制剂。采用分子建模和药物化学技术，对该系列化合物进行 SAR 研究，重点是消除潜在的代谢缺陷并提高细胞效力。
