使用异吲哚极性反转一锅法合成多环异吲哚啉。
One-pot synthesis of polycyclic isoindolines using isoindole umpolung.
作者信息
Weintraub Rachel A, He Wei, Wang Xiang
机构信息
Department of Chemistry, University of Colorado, Boulder, CO 80309, USA.
出版信息
Tetrahedron Lett. 2020 Jul 9;61(28). doi: 10.1016/j.tetlet.2020.152128. Epub 2020 Jun 7.
Abstract
Using an isoindole umpolung strategy, a one-pot synthesis of polycyclic isoindolines was accomplished. In this reaction, the -generated nucleophilic isoindoles were converted to electrophilic isoindoliums via protonation, which underwent a Pictet-Spengler-type cyclization to afford a variety of polycyclic isoindolines in good yields.
摘要
采用异吲哚极性翻转策略，实现了多环异吲哚啉的一锅法合成。在该反应中，生成的亲核异吲哚通过质子化转化为亲电异吲哚鎓，后者经历Pictet-Spengler型环化反应，以良好的产率得到了多种多环异吲哚啉。
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