Dalen Havard, Thorstensen Anders, Aase Svein A, Ingul Charlotte B, Torp Hans, Vatten Lars J, Stoylen Asbjorn
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Eur J Echocardiogr. 2010 Mar;11(2):176-83. doi: 10.1093/ejechocard/jep194. Epub 2009 Nov 28.
To study the distribution of longitudinal systolic strain and strain rate (SR) as indicators of myocardial deformation according to age and sex in a healthy population.
Longitudinal strain and SR were determined in 1266 healthy individuals from three standard apical views, using a combination of speckle tracking (ST) and tissue Doppler imaging (TDI) to track regions of interest (ROIs). To test applicability of the reference values, we used a subset of the population to compare four methods of assessing myocardial deformation: (1) a combination of TDI and ST; (2) TDI with fixed ROIs; (3) TDI with tracking of ROIs; and (4) ST. Mean (SD) overall global longitudinal strain and SR were -17.4% (2.3) and -1.05 s(-1) (0.13) in women, and -15.9% (2.3) and -1.01 s(-1) (0.13) in men. Deformation indices decreased with increasing age. The combined and ST methods showed identical SR, but values were significantly lower than those obtained by TDI. Strain was overestimated by the ST method (18.4%) compared with the combined method (17.4%).
The reference values for global and segmental longitudinal strain and SR obtained from this population study are applicable for use in a wide clinical setting.
研究在健康人群中，作为心肌变形指标的纵向收缩期应变和应变率（SR）按年龄和性别的分布情况。
使用斑点追踪（ST）和组织多普勒成像（TDI）相结合的方法，从三个标准心尖视图对1266名健康个体进行纵向应变和SR的测定，以追踪感兴趣区域（ROI）。为测试参考值的适用性，我们使用了一部分人群来比较四种评估心肌变形的方法：（1）TDI和ST相结合；（2）固定ROI的TDI；（3）追踪ROI的TDI；（4）ST。女性的平均（标准差）总体整体纵向应变和SR分别为-17.4%（2.3）和-1.05 s⁻¹（0.13），男性分别为-15.9%（2.3）和-1.01 s⁻¹（0.13）。变形指数随年龄增长而降低。联合法和ST法显示出相同的SR，但数值显著低于TDI法获得的值。与联合法（17.4%）相比，ST法高估了应变（18.4%）。
从该人群研究中获得的整体和节段性纵向应变及SR的参考值适用于广泛的临床环境。
