Watanabe Miho, Yamaguchi Keiichi, Yamanishi Tomonori, Kamai Takao, Yoshida Ken-Ichiro
The Department of Urology, Dokkyo University School of Medicine, Japan.
Hinyokika Kiyo. 2009 Nov;55(11):715-9.
A 51-year-old woman with a chief complaint of micturition pain and sensation of incomplete voiding was suspected of suffering from a bladder tumor, according to the findings of cystoscopy and ultrasonography. Transurethral punch biopsy of the submucosa of the bladder wall revealed eosinophilic infiltration without malignancy. Conservative treatment with corticosteroids resulted in excellent relief of symptoms and objective remission of the bladder lesions. However, her symptoms recurred 11 weeks after finishing the treatment. She was then treated with a combination of corticosteroid and suplatast tosilate, followed by monotherapy with suplatast tosilate. The treatment was effective for the improvement of symptoms, and serum immunoglobulin E and blood eosinophil levels were reduced. No disease progression was noted after the treatment with suplatast tosilate. To our knowledge, this is the first case of eosinophilic cystitis treated with suplatast tosilate.
一名51岁女性，以排尿疼痛和排尿不尽感为主诉，根据膀胱镜检查和超声检查结果怀疑患有膀胱肿瘤。经尿道膀胱壁黏膜下穿刺活检显示嗜酸性粒细胞浸润，无恶性病变。使用皮质类固醇进行保守治疗后症状得到显著缓解，膀胱病变客观缓解。然而，治疗结束11周后症状复发。随后她接受了皮质类固醇和甲苯磺酸舒普拉泰联合治疗，之后改为甲苯磺酸舒普拉泰单药治疗。该治疗对症状改善有效，血清免疫球蛋白E和血液嗜酸性粒细胞水平降低。使用甲苯磺酸舒普拉泰治疗后未观察到疾病进展。据我们所知，这是首例使用甲苯磺酸舒普拉泰治疗的嗜酸性膀胱炎病例。
