Kusumoto H, Mizuno K, Yonemaru M, Nakano M, Ichinose Y, Toyama K
First Department of Internal Medicine, Tokyo Medical College, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1997 May;35(5):550-4.
The patient was a 59-year-old woman who complained of coughing, sputum production, and dyspnea. Abnormal moving shadows were found by chest radiography. There was prolonged eosinophilia in blood. Eosinophilia was also found in bronchoalveolar lavage fluid, and examination of a specimen obtained by transbronchial lung biopsy revealed eosinophil infiltration in alveolar septal walls, which led to a diagnosis of chronic eosinophilic pneumonia. Because of an attack of bronchial asthma and a high level of IL-5 in serum on admission, the patient was given suplatast tosilate. Symptoms were relieved, eosinophil counts in blood and in bronchoalveolar lavage fluid decreased, and the radiographic abnormality disappeared. The patient was not treated with steroids, and there has been no reccurrence to date, one year after discharge.
患者为一名59岁女性,主诉咳嗽、咳痰及呼吸困难。胸部X线检查发现异常移动阴影。血液中嗜酸性粒细胞增多持续存在。支气管肺泡灌洗液中也发现嗜酸性粒细胞增多,经支气管肺活检获取的标本检查显示肺泡间隔壁有嗜酸性粒细胞浸润,从而诊断为慢性嗜酸性粒细胞性肺炎。由于入院时发作支气管哮喘且血清白细胞介素-5水平较高,给予患者甲苯磺酸舒普拉泰治疗。症状缓解,血液及支气管肺泡灌洗液中的嗜酸性粒细胞计数下降,影像学异常消失。患者未接受类固醇治疗,出院一年后的目前尚无复发情况。