The University of Ottawa, The Ottawa Hospital, Ottawa, Ontario, Canada.
Bone Marrow Transplant. 2010 Jul;45(7):1220-6. doi: 10.1038/bmt.2009.330. Epub 2009 Nov 30.
This retrospective single-center study compared the incidence, spectrum and effect of infections in 1045 consecutive allogeneic (allo) and autologous (auto) hematopoietic SCT (HSCT) performed between 1995 and 2006 in the inpatient (IP) or outpatient (OP) setting. We analyzed 374 allo-HSCT (196 IP and 178 OP) and 671 auto-HSCT (163 IP and 508 OP). The incidence of infection was lower both in auto-OP (25% OP vs 33% IP, P=0.042) and allo-OP cohorts (42.7% OP vs 55.6% IP, P=0.012). The mean number of infections per transplant was lower in both auto-OP (0.39 OP vs 0.57 IP, P=0.05) and in allo-OP cohorts (0.78 OP vs 1.09 IP, P=0.018). The 100-day non-relapse mortality (NRM) for OP auto-HSCT was 4.72% and for IP 3.95% (P=0.68). The 100-day NRM for OP allo-HSCT was lower at 14.1% than it was for IP at 22.6% (P=0.041). Time to onset of first infection and spectrum of infections was similar in all groups. We conclude that performing allo- and auto-HSCT in the OP setting results in short-term outcomes, including infections complications that are comparable to the standard IP setting.
这项回顾性单中心研究比较了 1995 年至 2006 年期间在住院（IP）或门诊（OP）环境中连续进行的 1045 例同种异体（allo）和自体（auto）造血干细胞移植（HSCT）中感染的发生率、谱和影响。我们分析了 374 例 allo-HSCT（196 例 IP 和 178 例 OP）和 671 例 auto-HSCT（163 例 IP 和 508 例 OP）。感染发生率在 auto-OP（25% OP 与 33% IP，P=0.042）和 allo-OP 队列中均较低（42.7% OP 与 55.6% IP，P=0.012）。在这两个队列中，auto-OP（0.39 OP 与 0.57 IP，P=0.05）和 allo-OP（0.78 OP 与 1.09 IP，P=0.018）中每例移植的感染次数均较低。OP auto-HSCT 的 100 天非复发死亡率（NRM）为 4.72%，而 IP 为 3.95%（P=0.68）。OP allo-HSCT 的 100 天 NRM 为 14.1%，低于 IP 的 22.6%（P=0.041）。所有组中首次感染的发病时间和感染谱相似。我们得出结论，在 OP 环境中进行 allo 和 auto-HSCT 可获得短期结果，包括感染并发症，与标准的 IP 环境相当。
