Hematology Department, Hospital Universitario de Melilla, Melilla, Spain.
Hematology Department, Bone Marrow Transplantation Unit, Instituto del Cáncer y Enfermedades de la Sangre (ICAMS), Hospital Clínic, Barcelona, Spain.
Front Immunol. 2024 Jul 16;15:1419186. doi: 10.3389/fimmu.2024.1419186. eCollection 2024.
Autologous stem-cell transplantation (ASCT) is the standard of care for the management of multiple myeloma and has a well-established role in the treatment of some types of lymphoma. Over the last decades, the number of ASCT performed has increased significantly, leading to elevated pressure and cost for healthcare services. Conventional model of ASCT includes the admission of patients to a specialized Transplant Unit at any stage of the procedure. To optimize healthcare provision, ambulatory (outpatient/at-home) setting should be the focus moving forward. Thus, ambulatory ASCT model permits reducing average hospital stays and pressures on healthcare services, with significant cost-saving benefits and high degree of patient and caregiver satisfaction. In addition, it facilitates the bed resource for other complex procedures such as allografts or CAR-T cell therapy. The aim of this systematic review is to document the health impact, feasibility and safety of the outpatient/at-home ASCT models, which are increasingly being applied around the world.
自体干细胞移植 (ASCT) 是多发性骨髓瘤治疗的标准方法，在某些类型的淋巴瘤治疗中也具有明确的作用。在过去几十年中，ASCT 的数量显著增加，导致医疗保健服务的压力和成本增加。传统的 ASCT 模式包括在程序的任何阶段将患者收治到专门的移植病房。为了优化医疗保健服务，应将门诊（门诊/居家）模式作为未来的重点。因此，门诊 ASCT 模式可以减少平均住院时间和医疗保健服务的压力，具有显著的节省成本效益和高度的患者和护理人员满意度。此外，它还为其他复杂程序（如同种异体移植或 CAR-T 细胞治疗）提供了床位资源。本系统评价的目的是记录门诊/居家 ASCT 模式的健康影响、可行性和安全性，该模式在全球范围内得到了越来越多的应用。
