Chen Ruimin, Mick Gail J, Xu Rongxian, Zheng Daoxin, Fan Yanfeng, Lin Xiangquan, McCormick Kenneth L
Department of Endocrinology, Fuzhou Children's Hospital of Fujian, Fuzhou 350005, China.
Int J Pediatr Endocrinol. 2009;2009:194807. doi: 10.1155/2009/194807. Epub 2009 Sep 13.
The effect of intracerebroventricular (ICV) antileptin antibody on the onset of puberty in the female rat and the relationship between serum leptin, luteinizing hormone (LH), and body weight were investigated. Antileptin antibody (group A) was infused ICV from days 23-36 in prepubertal female rats whereas the control (group B) received ICV goat immunoglobulin G (IgG). In the antileptin group, mean day of vaginal opening (VO) was postponed (day 34 versus day 30, P < .01 ). Body weight trended higher after 30 days in the antileptin group but not significantly. However, there was no difference in serum leptin and LH between the two groups on the day of VO. Serum leptin was relatively constant from day 23 through day 31 and did not correlate with LH (r = 0.14, P = .10). These studies demonstrate that central leptin promotes the onset of female rat puberty as evidenced by VO. Finally, central leptin impacts female rat pubertal onset in distinction from serum leptin and body weight.
研究了脑室内（ICV）注射抗瘦素抗体对雌性大鼠青春期启动的影响以及血清瘦素、促黄体生成素（LH）和体重之间的关系。在青春期前雌性大鼠的第23至36天，向其脑室内注射抗瘦素抗体（A组），而对照组（B组）接受脑室内注射山羊免疫球蛋白G（IgG）。在抗瘦素组中，平均阴道开口（VO）天数推迟（第34天对第30天，P <.01）。抗瘦素组在30天后体重有升高趋势，但不显著。然而，在VO当天，两组之间的血清瘦素和LH没有差异。从第23天到第31天，血清瘦素相对恒定，且与LH无相关性（r = 0.14，P =.10）。这些研究表明，中枢瘦素促进雌性大鼠青春期启动，VO可作为证据。最后，中枢瘦素影响雌性大鼠青春期启动，这与血清瘦素和体重不同。
