Department of Endocrinology, Genetics and Metabolism, Fuzhou Children's Hospital of Fujian Medical University, Fuzhou, China.
Int J Public Health. 2023 May 15;68:1605433. doi: 10.3389/ijph.2023.1605433. eCollection 2023.
To investigate the associations of obesity with growth and puberty in children. From November 2017 to December 2019, height, weight, and Tanner stages of 26,879 children aged 3-18 years in Fuzhou, China were assessed. The obese group was significantly taller than the non-obese group after age 4 years for both genders, yet there was no significant difference in height between obese and non-obese group after 15.5 years old for boys and 12.5 years old for girls. The inflection points of significant growth deceleration in obese and non-obese groups were 14.4 and 14.6 years old for boys, and 11.8 and 12.8 years old for girls, respectively. The proportions of testicular development in boys with obesity and non-obesity were 7.96% and 5.08% at 8.5-8.9 years old, respectively, while the proportions of breast development in girls were 17.19% and 3.22% at age 7.5-7.9 years old, respectively. Children with obesity were taller in early childhood, earlier onset of puberty and earlier cessation of growth than children with non-obesity of the same age. However, there was sex dimorphism on the effect of obesity on the incidence of precocious puberty.
探讨肥胖与儿童生长和青春期发育的关系。2017 年 11 月至 2019 年 12 月，对中国福州 26879 名 3-18 岁儿童的身高、体重和 Tanner 分期进行评估。肥胖组的身高明显高于非肥胖组，且在 4 岁以后的各个年龄段，无论男女，这种差异均具有统计学意义。但在 15.5 岁以后，男孩的身高与肥胖组和非肥胖组之间没有显著差异，女孩的身高在 12.5 岁以后也没有显著差异。肥胖组和非肥胖组的生长减速拐点分别为男孩 14.4 岁和 14.6 岁，女孩 11.8 岁和 12.8 岁。肥胖男孩的睾丸发育比例为 7.96%，而非肥胖男孩的睾丸发育比例为 5.08%，分别在 8.5-8.9 岁和 8.5-8.9 岁达到高峰；肥胖女孩的乳房发育比例为 17.19%，而非肥胖女孩的乳房发育比例为 3.22%，分别在 7.5-7.9 岁和 7.5-7.9 岁达到高峰。肥胖儿童在幼儿期身高较高，青春期开始较早，生长停止较早。然而，肥胖对性早熟发生率的影响存在性别二态性。
