Kern S B
Medical Arts Laboratory, Oklahoma City, Oklahoma.
Acta Cytol. 1991 Jan-Feb;35(1):81-8.
Reports from sequential series of 234,318 cervicovaginal smears from a period of three years were reviewed to ascertain the prevalence and significance of psammoma bodies. Seven smears contained psammoma bodies. Three of the seven were associated with benign conditions and four were associated with a cancer (two serous papillary endometrial adenocarcinomas, one ovarian serous cystadenocarcinoma and one serous papillary carcinoma of the peritoneum). The prevalence of psammoma bodies in benign cases was much higher than reported in previous studies, in which most findings of psammoma bodies were associated with malignancy, particularly ovarian carcinoma. A consistent and useful feature in distinguishing psammoma bodies associated with benign or malignant disease was the presence of a few adherent small bland-appearing glandular cells in benign disorders and adherent malignant glandular cells in cases of carcinoma. A more conservative work-up may be merited in young women with clearly benign cells associated with psamoma bodies in a cervicovaginal smear and an otherwise negative physical examination and noncontributory endometrial sampling.
回顾了连续三年234,318份宫颈阴道涂片的报告，以确定砂粒体的患病率及其意义。七份涂片含有砂粒体。七份中的三份与良性疾病相关，四份与癌症相关（两份浆液性乳头状子宫内膜腺癌、一份卵巢浆液性囊腺癌和一份腹膜浆液性乳头状癌）。良性病例中砂粒体的患病率远高于以往研究报告，以往砂粒体的大多数发现都与恶性肿瘤相关，尤其是卵巢癌。区分与良性或恶性疾病相关的砂粒体的一个一致且有用的特征是，良性疾病中存在一些附着的外观温和的小腺细胞，而癌病例中存在附着的恶性腺细胞。对于宫颈阴道涂片中有与砂粒体相关的明显良性细胞、体格检查阴性且子宫内膜取样无异常的年轻女性，可能值得进行更保守的检查。
