Yoon Richard K, Chussid Steven
Division of Pediatric Dentistry, Columbia University College of Dental Medicine, New York City, NY, USA.
Pediatr Dent. 2009 Sep-Oct;31(5):377-81.
The purpose of this prospective study was to compare the efficacy of Oraqix to benzocaine while placing a rubber dam clamp during sealant placement on children.
A sample size of 45 7- to 12-year-old patients who presented for bilateral sealants on permanent first molars participated in this study. A split-mouth design was implemented with Oraqix applied to one side and 20 percent benzocaine gel applied to the other. After placing the topical anesthetic and the rubber dam clamp, patients completed a Feces Pain Scale (FPS) to rate the level of discomfort after clamp placement.
Twenty-seven subjects (60%) were female and 18 subjects (40%) were mole; 15 (33%) were younger than 9 years old and 30 (67%) were at least 9 years old. The overall difference in mean FPS ratings was not statistically significant (P = .27). Regarding gender, there was no statistically significant difference in males (P = .65) or females (P = .26). There was also no difference in mean FPS ratings when looking at age groups younger than 9 years old with P=.77 In the 9 years and older age groups, however there was a statistically significant difference, with P = .04.
Application of Oraqix did not reduce discomfort when compared to benzocaine in this small sample size. Oraqix was more effective than benzocaine in the age group 9 and older. A larger sample size is needed to determine its efficacy in children younger than 9years old.
这项前瞻性研究的目的是比较在儿童放置窝沟封闭剂时使用奥克赛（Oraqix）和苯佐卡因放置橡皮障夹的效果。
45名7至12岁前来为恒第一磨牙进行双侧窝沟封闭的患者参与了本研究。采用双侧对照设计，一侧使用奥克赛，另一侧使用20%苯佐卡因凝胶。在涂抹局部麻醉剂和放置橡皮障夹后，患者完成面部疼痛量表（FPS）以评估放置夹子后的不适程度。
27名受试者（60%）为女性，18名受试者（40%）为男性；15名（33%）年龄小于9岁，30名（67%）至少9岁。平均FPS评分的总体差异无统计学意义（P = 0.27）。在性别方面，男性（P = 0.65）或女性（P = 0.26）均无统计学显著差异。在年龄小于9岁的组中，平均FPS评分也无差异（P = 0.77）。然而，在9岁及以上年龄组中，存在统计学显著差异，P = 0.04。
在这个小样本中，与苯佐卡因相比，使用奥克赛并未减轻不适。在9岁及以上年龄组中，奥克赛比苯佐卡因更有效。需要更大样本量来确定其在9岁以下儿童中的疗效。
