Ravari H, Zafarghandi M R, Alvandfar D, Saadat S
Iman Reza Hospital, Mashhad University of Medical Sciences, Iran.
Pak J Biol Sci. 2009 Jul 15;12(14):1019-24. doi: 10.3923/pjbs.2009.1019.1024.
This study was aimed to evaluate the association of serum homocysteine with peripheral atherosclerosis and deep vein thrombosis in an Iranian population complaining from vascular symptoms in lower limbs referred to a university general hospital in the capital of Iran. The study design was case-control. Deep vein thrombosis and atherosclerosis groups were, respectively consisted of 25 patients presenting with signs and symptoms of deep vein thrombosis whom disease was confirmed by duplex ultrasonography and 25 patients presenting with signs and symptoms of chronic arterial insufficiency who were candidate for arterial reconstruction whom disease was confirmed by angiography. The control group was consisted of 25 persons selected among relatives accompanying the traumatic patients admitted in the general surgery ward of the same hospital. The age of atherosclerosis, DVT and control group were 61 +/- 14, 47 +/- 16 and 40 +/- 14, respectively. The serum level of homocysteine was higher in males (p < 0.01) except for atherosclerotic patients. The prevalence of high homocysteine was 15% (control), 36% (DVT) and 56% (atherosclerosis) among females and 75% (control), 73% (DVT) and 56% (atherosclerosis) among males. The serum homocysteine in the control group which was representative of Tehran population who do not take vitamin B supplements was unexpectedly high. It seems that fortification of popular foodstuffs should be considered for Tehran. The association between homocysteine and atherosclerosis and deep vein thrombosis was not confirmed in this study especially for men who had higher serum homocysteine than women. It is possible that this association fades away in populations with high prevalence of hyperhomocysteinema.
本研究旨在评估在一家位于伊朗首都的大学综合医院就诊的、有下肢血管症状的伊朗人群中，血清同型半胱氨酸与外周动脉粥样硬化及深静脉血栓形成之间的关联。研究设计为病例对照研究。深静脉血栓形成组和动脉粥样硬化组分别由25例患者组成，其中深静脉血栓形成组患者表现出深静脉血栓形成的体征和症状，其疾病经双功超声检查确诊；动脉粥样硬化组患者表现出慢性动脉供血不足的体征和症状，为动脉重建候选者，其疾病经血管造影确诊。对照组由在同一家医院普通外科病房住院的创伤患者的陪同亲属中选取的25人组成。动脉粥样硬化组、深静脉血栓形成组和对照组的年龄分别为61±14岁、47±16岁和40±14岁。除动脉粥样硬化患者外，男性的血清同型半胱氨酸水平较高（p<0.01）。女性中高同型半胱氨酸的患病率在对照组为15%、深静脉血栓形成组为36%、动脉粥样硬化组为56%；男性中分别为75%、73%和56%。对照组代表不补充维生素B的德黑兰人群，其血清同型半胱氨酸水平出乎意料地高。似乎应该考虑对德黑兰的大众食品进行强化。本研究未证实同型半胱氨酸与动脉粥样硬化及深静脉血栓形成之间的关联，尤其是对于血清同型半胱氨酸水平高于女性的男性。在高同型半胱氨酸血症患病率高的人群中，这种关联可能会消失。
