Lukás K, Zák A
IV interní klinika 1. lékarské fakulty UK a VFN Praha.
Vnitr Lek. 2009 Oct;55(10):949-54.
Gastroesophageal reflux disease is defined as a disorder where reflux of the stomach content is bothersome and/or brings about complications. A condition, where reflux symptoms persist or new occur and oesophagitis healing fails to take place despite maximum treatment, is classified as refractory gastroesophageal reflux disease. A motility disorder rather than acid hypersecretion is the most important cause of gastroesophageal reflux disease. Prokinetic agents are thus the most logical treatment choice for gastroesophageal reflux disease, although proton pump inhibitors or, alternatively, a combination of these two therapeutic groups are the most effective.
胃食管反流病被定义为一种胃内容物反流令人烦恼和/或导致并发症的病症。尽管进行了最大程度的治疗，但反流症状持续存在或新出现且食管炎未能愈合的情况，被归类为难治性胃食管反流病。动力障碍而非胃酸分泌过多是胃食管反流病的最重要原因。因此，促动力剂是胃食管反流病最合理的治疗选择，尽管质子泵抑制剂或这两类治疗药物的联合使用是最有效的。
