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74例喉白斑病的临床与病理分析

[Clinic and pathological analysis the larynx leukoplakia in 74 cases].

作者信息

Yu He, Li Xiaotian, Wang Yan, Yang Huaian, Guo Xing, Pan Zimin, Jiang Xuejun

机构信息

Department of Otolaryngology, the First Affiliated Hospital of China Medical University, Shenyang, 110001, China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Aug;23(15):688-9.

Abstract

OBJECTIVE

To study the clinic and pathological features of leukoplakia of the larynx, and reduce canceration rate.

METHOD

Seventy-four postoperative patients of leukoplakia of the larynx were followed up for four years by telephone or clinic service.

RESULT

None of eighteen cases of pure leukoplakia was recurrence. Fifty-six cases were leukoplakia with epithelial dysplasia histologically. Seven out of fifty-six postoperative cases occurred hoarseness; three out of fifty-six postoperative cases recurred, and accepted twice or more operations successively; three out of fifty-six postoperative cases occurred canceration.

CONCLUSION

Operation is the main means for the treatment of leukoplakia of the larynx, and the effect is comparatively well. The patients with histological epithelial dysplasia should be pay great attention because of their higher canceration rate, and enlarged operation ranges appropriately with the patient consent could effectually prevent recurrence or canceration during the early lesions. Close observation is important for these patients.

摘要

目的

探讨喉白斑病的临床及病理特征,降低癌变率。

方法

对74例喉白斑病术后患者通过电话或门诊随访4年。

结果

18例单纯性白斑无一例复发。56例组织学表现为上皮发育异常的白斑。56例术后患者中有7例出现声音嘶哑;56例术后患者中有3例复发,并先后接受了两次或更多次手术;56例术后患者中有3例发生癌变。

结论

手术是治疗喉白斑病的主要手段,效果较好。组织学上皮发育异常的患者因其癌变率较高应予以高度重视,在征得患者同意的情况下适当扩大手术范围可有效预防早期病变的复发或癌变。对这些患者进行密切观察很重要。

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