手性 PYBOX-DIPH-Zn(II) 配合物催化吡咯的不对称 Friedel-Crafts 烷基化反应。
Enantioselective Friedel-Crafts alkylation of pyrroles catalyzed by PYBOX-DIPH-Zn(II) complexes.
机构信息
Department of Chemistry, Indian Institute of Technology, Kanpur, India 208 016.
出版信息
Org Lett. 2010 Jan 1;12(1):80-3. doi: 10.1021/ol902360b.
PMID:19947623
Abstract
A highly enantioselective Friedel-Crafts alkylation of pyrroles with 2-enoylpyridine N-oxides catalyzed by chiral PYBOX-DIPH-Zn(II) complexes has been developed. The catalyst offers substantial substrate scope and furnished alkylated pyrroles in excellent yields (up to 99%) and enantioselectivities (up to >99% ee).
摘要
手性 PYBOX-DIPH-Zn(II) 配合物催化的吡咯与 2-烯酰基吡啶 N-氧化物的高对映选择性 Friedel-Crafts 烷基化反应已经被开发出来。该催化剂具有广泛的底物适用性，能够以优异的收率（高达 99%）和对映选择性（高达 >99%ee）得到烷基化的吡咯产物。
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