手性和区域选择性的铟(III)催化吡咯与色酮的加成反应。
Enantioselective and regioselective indium(III)-catalyzed addition of pyrroles to isatins.
机构信息
Department of Chemistry, University of California , One Shields Avenue, Davis, California 95616, USA.
出版信息
Org Lett. 2011 Nov 4;13(21):5754-7. doi: 10.1021/ol202329s. Epub 2011 Oct 11.
Abstract
The indium(III)-catalyzed enantioselective and regioselective addition of pyrroles to isatins is described. The effects of metal and solvent on the reactivity and selectivity are compared and discussed, demonstrating that the indium(III)-indapybox complex provides the most effective catalyst. A case of divergent reactivity between pyrroles and indoles is presented.
摘要
本文描述了铟(III)催化吡咯与色酮的对映选择性和区域选择性加成反应。比较和讨论了金属和溶剂对反应活性和选择性的影响，结果表明，铟(III)-吲哚啉酮配合物提供了最有效的催化剂。还提出了吡咯和吲哚之间反应活性差异的情况。
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