Indian Institute of Toxicology Research (Council of Scientific and Industrial Research), Lucknow, India.
Chem Biol Interact. 2010 Feb 12;183(3):333-40. doi: 10.1016/j.cbi.2009.11.028. Epub 2009 Dec 3.
Pyrogallol, a potent anti-psoriatic drug, produces toxicity due to its ability to generate free radicals, besides its beneficial effects. Oxidative stress is implicated in pyrogallol-mediated toxicity in general and hepatotoxicity in particular. Naturally occurring antioxidants including, resveratrol and silymarin have been proposed as potential supplements to counteract pyrogallol-mediated toxicity, without reducing its efficacy. Due to increase in the popularity of natural antioxidants in combating pyrogallol-mediated toxicity, a literature-based survey was performed to assess their role in experimental studies and possible implications in real life situations. Although preclinical studies revealed the boons of naturally occurring antioxidants in attenuating/abolishing the undesirable effects of pyrogallol exposure, limited studies have been conducted to evaluate their role in clinics. In this review, an update on the recent development in assessing the potential of natural antioxidants in pyrogallol-mediated toxicity in preclinical interventions, triumphs and pitfalls of such investigations, their translational challenges and future possibilities are discussed.
焦性没食子酸是一种有效的抗银屑病药物，但由于其产生自由基的能力，除了有益的作用外，还会产生毒性。氧化应激与焦性没食子酸介导的毒性有关，特别是肝毒性。天然存在的抗氧化剂，包括白藜芦醇和水飞蓟素，已被提议作为对抗焦性没食子酸介导的毒性的潜在补充剂，而不降低其疗效。由于天然抗氧化剂在对抗焦性没食子酸介导的毒性方面的普及度增加，因此进行了基于文献的调查，以评估它们在实验研究中的作用及其在实际情况中的可能影响。尽管临床前研究显示天然抗氧化剂在减轻/消除焦性没食子酸暴露的不良影响方面具有优势，但在临床方面进行的研究有限。在这篇综述中，讨论了评估天然抗氧化剂在焦性没食子酸介导的毒性的临床前干预中的潜力的最新进展，以及这些研究的成功和挑战、它们的转化挑战和未来的可能性。
