Research Institute, Division of Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada.
FEBS Lett. 2010 May 3;584(9):1879-86. doi: 10.1016/j.febslet.2009.11.089. Epub 2009 Dec 2.
The glycosphingolipid globotriaosyl ceramide, (Galalpha1-4Galss1-4 glucosyl ceramide-Gb(3)) also known as CD77 and the P(k) blood group antigen, is bound by both verotoxins and by the HIV adhesin, gp120. Gb(3) plays an important receptor role in VT induced hemolytic uremic syndrome (HUS) and HIV infection. The organization of glycolipids, including Gb(3), into lipid rafts is central to both pathologies. The fatty acid heterogeneity within the Gb(3) lipid moiety plays a central role in assembly within such ordered domains. Differential binding of verotoxins and gp120 to such Gb(3) isoforms in model and cell membranes indicates a significant role in the eventual pathogenic outcome. HUS may provide the first example whereby membrane Gb(3) organization provides a predictor for tissue selective in vivo pathology.
神经节苷脂糖脂Globotriaosyl Ceramide（Galalpha1-4Galss1-4 glucosyl Ceramide-Gb（3）），也被称为 CD77 和 P（k）血型抗原，被两种志贺毒素和 HIV 黏附物 gp120 结合。Gb（3）在志贺毒素引起的溶血尿毒综合征（HUS）和 HIV 感染中起着重要的受体作用。包括 Gb（3）在内的糖脂的组织，形成脂筏，这是两种病理学的核心。Gb（3）脂质部分的脂肪酸异质性在这些有序结构域的组装中起着核心作用。在模型和细胞膜中，志贺毒素和 gp120 对这种 Gb（3）同工型的不同结合表明，在最终的致病结果中起着重要作用。HUS 可能提供了第一个例子，即膜 Gb（3）的组织为体内组织选择性病理提供了预测。
