School of Materials and Engineering, Tianjin Key Lab of Fiber Modification & Functional Fiber, Tianjin Polytechnic University, Tianjin 300160, China.
J Colloid Interface Sci. 2010 Feb 15;342(2):607-13. doi: 10.1016/j.jcis.2009.10.073. Epub 2009 Oct 31.
MCM-41 was grafted with 3-aminopropyl trimethoxysilane (APTMS), 3-chloropropyltriethoxysilane (CPTMS) to give organic group modified samples, and l-tryptophane was covalently immobilized onto organic samples to improve the physicochemical properties of mesoporous silica to controlled amoxicillin delivery. Samples were characterized by X-ray diffraction (XRD), N(2) adsorption-desorption isotherms and Fourier transform infrared (FT-IR) spectroscopy, and characterized results demonstrated that organic groups were successfully grafted onto the samples. The results of amoxicillin release exhibited that 12.9wt% and 33.0wt% impregnated amoxicillin could be released from the post-grafting MCM-41 with APTMS and pure MCM-41 after 24h, however, 41.0wt% impregnated amoxicillin could be released from the post-grafting MCM-41 with CPTMS after 24h. When the samples modified with APTMS and CPTMS were further grafted by l-tryptophane, the slower drug release rate was achieved over samples with l-tryptophane immobilization. The release profiles of all samples indicated that the amoxicillin release was mainly regulated by the diffusion mechanism.
MCM-41 用 3-氨丙基三甲氧基硅烷 (APTMS)、3-氯丙基三乙氧基硅烷 (CPTMS) 接枝，得到有机基团改性样品，并将 l-色氨酸共价固定在有机样品上，以改善介孔硅的物理化学性质，实现阿莫西林的控释。采用 X 射线衍射 (XRD)、N2 吸附-脱附等温线和傅里叶变换红外 (FT-IR) 光谱对样品进行了表征，表征结果表明有机基团成功接枝到样品上。阿莫西林释放结果表明，接枝 APTMS 的后处理 MCM-41 和纯 MCM-41 在 24h 后可释放出 12.9wt%和 33.0wt%的负载阿莫西林，而接枝 CPTMS 的后处理 MCM-41 在 24h 后可释放出 41.0wt%的负载阿莫西林。当用 APTMS 和 CPTMS 进一步修饰接枝 l-色氨酸的样品时，固定 l-色氨酸的样品达到了更慢的药物释放速率。所有样品的释放曲线表明，阿莫西林的释放主要受扩散机制的调节。
