Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, China.
Center for Basic Medical Research, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Drug Deliv. 2020 Dec;27(1):200-215. doi: 10.1080/10717544.2020.1716878.
With the development of nanotechnology, self-assembled chitosan/phospholipid nanoparticles (SACPNs) show great promise in a broad range of applications, including therapy, diagnosis, in suit imaging and on-demand drug delivery. Here, a brief review of the SACPNs is presented, and its critical underlying formation mechanisms are interpreted with an emphasis on the intrinsic physicochemical properties. The state-of-art preparation methods of SACPNs are summarized, with particular descriptions about the classic solvent injection method. Then SACPNs microstructures are characterized, revealing the unique spherical core-shell structure and the drug release mechanisms. Afterwards, a comprehensive and in-depth depiction of their emerging applications, with special attention to drug delivery areas, are categorized and reviewed. Finally, conclusions and outlooks on further advancing the SACPNs toward a more powerful and versatile platform for investigations covering from fundamental understanding to developing multi-functional drug delivery systems are discussed.
随着纳米技术的发展，自组装壳聚糖/磷脂纳米粒（SACPNs）在广泛的应用中具有广阔的前景，包括治疗、诊断、在体成像和按需药物输送。本文简要综述了 SACPNs，并对其关键的基础形成机制进行了解释，重点是内在的物理化学性质。总结了 SACPNs 的最新制备方法，特别描述了经典的溶剂注入法。然后对 SACPNs 的微观结构进行了表征，揭示了其独特的球形核壳结构和药物释放机制。之后，对其新兴应用进行了全面而深入的描述，特别关注药物输送领域，并进行了分类和综述。最后，讨论了进一步推进 SACPNs 发展成为更强大和多功能的研究平台的结论和展望，涵盖从基础理解到开发多功能药物输送系统的各个方面。
