鉴定沙门氏菌 enterica damX 基因产物，一种参与胆盐抗性的内膜蛋白。
Identification of the Salmonella enterica damX gene product, an inner membrane protein involved in bile resistance.
机构信息
Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Apartado 1095, E-41080 Seville, Spain.
出版信息
J Bacteriol. 2010 Feb;192(3):893-5. doi: 10.1128/JB.01220-09. Epub 2009 Nov 30.
Abstract
The damX gene product of Salmonella enterica serovar Typhimurium is a protein located in the inner membrane. DamX migrates as a 70-kDa protein in SDS-PAGE even though the predicted protein size is 46 kDa. Synthesis of DamX protein occurs in both exponential- and stationary-phase cultures. Disruption of damX causes severe sensitivity to bile. Lack of the outer membrane protein AsmA suppresses bile sensitivity in Salmonella damX mutants.
摘要
肠沙门氏菌血清型鼠伤寒的 damX 基因产物是一种位于内膜的蛋白质。DamX 以 70 kDa 的蛋白形式在 SDS-PAGE 中迁移，尽管预测的蛋白大小为 46 kDa。DamX 蛋白的合成发生在指数和静止期培养物中。damX 的缺失导致对胆盐的严重敏感性。外膜蛋白 AsmA 的缺失抑制了沙门氏菌 damX 突变体的胆盐敏感性。
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