Science of self-preservation: how melanocortin action in the brain modulates body weight, blood pressure, and ischemic damage.
作者信息
Corander Marcus P, Fenech Matthew, Coll Anthony P
机构信息
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Hills Rd, Cambridge, CB2 0QQ UK.
出版信息
Circulation. 2009 Dec 1;120(22):2260-8. doi: 10.1161/CIRCULATIONAHA.109.854612.
Abstract
摘要
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本文引用的文献
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Modulation of blood pressure by central melanocortinergic pathways.中枢黑皮质素能通路对血压的调节
N Engl J Med. 2009 Jan 1;360(1):44-52. doi: 10.1056/NEJMoa0803085. Epub 2008 Dec 17.
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Vagus nerve mediates the protective effects of melanocortins against cerebral and systemic damage after ischemic stroke.迷走神经介导了黑皮质素对缺血性中风后脑损伤和全身损伤的保护作用。
J Cereb Blood Flow Metab. 2009 Mar;29(3):512-23. doi: 10.1038/jcbfm.2008.140. Epub 2008 Nov 19.
3
Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion.黑色素皮质素3型受体基因敲除小鼠缺血再灌注后肠系膜微循环的炎症表型
FASEB J. 2008 Dec;22(12):4228-38. doi: 10.1096/fj.08-113886. Epub 2008 Aug 29.
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Common variants near MC4R are associated with fat mass, weight and risk of obesity.MC4R基因附近的常见变异与脂肪量、体重及肥胖风险相关。
Nat Genet. 2008 Jun;40(6):768-75. doi: 10.1038/ng.140. Epub 2008 May 4.
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Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction.靶向黑皮质素受体：一种治疗体重紊乱和性功能障碍的方法。
Nat Rev Drug Discov. 2008 Apr;7(4):307-23. doi: 10.1038/nrd2331.
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Endogenous melanocortin system activity contributes to the elevated arterial pressure in spontaneously hypertensive rats.内源性黑皮质素系统活性导致自发性高血压大鼠动脉血压升高。
Hypertension. 2008 Apr;51(4):884-90. doi: 10.1161/HYPERTENSIONAHA.107.100636. Epub 2008 Feb 19.
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Cause-specific excess deaths associated with underweight, overweight, and obesity.与体重过轻、超重和肥胖相关的特定病因超额死亡。
JAMA. 2007 Nov 7;298(17):2028-37. doi: 10.1001/jama.298.17.2028.
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The central melanocortin system directly controls peripheral lipid metabolism.中枢黑皮质素系统直接控制外周脂质代谢。
J Clin Invest. 2007 Nov;117(11):3475-88. doi: 10.1172/JCI31743.
9
Effects of pro-opiomelanocortin (POMC) on food intake and body weight: mechanisms and therapeutic potential?促阿片-黑素细胞皮质素原（POMC）对食物摄入和体重的影响：作用机制及治疗潜力？
Clin Sci (Lond). 2007 Aug;113(4):171-82. doi: 10.1042/CS20070105.
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Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage.选择性黑皮质素MC4受体激动剂可逆转失血性休克并预防多器官损伤。
Br J Pharmacol. 2007 Mar;150(5):595-603. doi: 10.1038/sj.bjp.0707115. Epub 2007 Jan 22.
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