脑黑皮质素系统、交感神经控制与肥胖型高血压
The brain melanocortin system, sympathetic control, and obesity hypertension.
作者信息
da Silva Alexandre A, do Carmo Jussara M, Wang Zhen, Hall John E
机构信息
Department of Physiology and Biophysics, Mississippi Center for Obesity Research, and Cardiovascular-Renal Research Center, The University of Mississippi Medical Center, Jackson, Mississippi.
出版信息
Physiology (Bethesda). 2014 May;29(3):196-202. doi: 10.1152/physiol.00061.2013.
Abstract
Excess weight gain is the most significant, preventable cause of increased blood pressure (BP) in patients with primary (essential) hypertension and increases the risk for cardiovascular and renal diseases. In this review, we discuss the role of the brain melanocortin system in causing increased sympathetic activity in obesity and other forms of hypertension. In addition, we highlight potential mechanisms by which the brain melanocortin system modulates metabolic and cardiovascular functions.
摘要
体重过度增加是原发性（特发性）高血压患者血压升高最显著且可预防的原因，还会增加心血管疾病和肾脏疾病的风险。在本综述中，我们讨论了脑黑皮质素系统在肥胖及其他类型高血压中导致交感神经活动增加的作用。此外，我们重点介绍了脑黑皮质素系统调节代谢和心血管功能的潜在机制。
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