Atorvastatin as a potential antimalarial drug: in vitro synergy in combinational therapy with dihydroartemisinin.
作者信息
Savini Hélène, Souraud Jean Baptiste, Briolant Sébastien, Baret Eric, Amalvict Rémy, Rogier Christophe, Pradines Bruno
出版信息
Antimicrob Agents Chemother. 2010 Feb;54(2):966-7. doi: 10.1128/AAC.01006-09. Epub 2009 Nov 30.
Abstract
摘要
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本文引用的文献
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Atorvastatin is a promising partner for antimalarial drugs in treatment of Plasmodium falciparum malaria.阿托伐他汀是治疗恶性疟原虫疟疾的抗疟药物的一个有前景的伙伴。
Antimicrob Agents Chemother. 2009 Jun;53(6):2248-52. doi: 10.1128/AAC.01462-08. Epub 2009 Mar 23.
2
Plasmodium falciparum Na+/H+ exchanger 1 transporter is involved in reduced susceptibility to quinine.恶性疟原虫的钠/氢交换体1转运蛋白与对奎宁的敏感性降低有关。
Antimicrob Agents Chemother. 2009 May;53(5):1926-30. doi: 10.1128/AAC.01243-08. Epub 2009 Mar 9.
3
Statins as potential antimalarial drugs: low relative potency and lack of synergy with conventional antimalarial drugs.他汀类药物作为潜在的抗疟药物：相对效力较低且与传统抗疟药物缺乏协同作用。
Antimicrob Agents Chemother. 2009 May;53(5):2212-4. doi: 10.1128/AAC.01469-08. Epub 2009 Mar 2.
4
Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment.在持续使用13年期间，泰国西北边境地区对青蒿琥酯-甲氟喹治疗反应的变化。
PLoS One. 2009;4(2):e4551. doi: 10.1371/journal.pone.0004551. Epub 2009 Feb 23.
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Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia.青蒿琥酯-甲氟喹联合疗法治疗柬埔寨南部非复杂性恶性疟原虫疟疾失败。
Malar J. 2009 Jan 12;8:10. doi: 10.1186/1475-2875-8-10.
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A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis.脓毒症重症患者阿托伐他汀血浆浓度的初步研究。
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Molecular surveillance for multidrug-resistant Plasmodium falciparum, Cambodia.柬埔寨对耐多药恶性疟原虫的分子监测
Emerg Infect Dis. 2008 Oct;14(10):1637-40. doi: 10.3201/eid1410.080080.
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Dihydroethanoanthracene derivatives reverse in vitro quinoline resistance in Plasmodium falciparum malaria.二氢蒽衍生物可逆转恶性疟原虫疟疾的体外喹啉抗性。
Med Chem. 2008 Sep;4(5):426-37. doi: 10.2174/157340608785700234.
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Statins alone are ineffective in cerebral malaria but potentiate artesunate.他汀类药物单独使用对脑型疟疾无效，但可增强青蒿琥酯的疗效。
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10
Atorvastatin is 10-fold more active in vitro than other statins against Plasmodium falciparum.阿托伐他汀在体外对恶性疟原虫的活性比其他他汀类药物高10倍。
Antimicrob Agents Chemother. 2007 Jul;51(7):2654-5. doi: 10.1128/AAC.01330-06. Epub 2007 May 14.
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