Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Br J Psychiatry. 2009 Dec;195(6):492-7. doi: 10.1192/bjp.bp.109.065227.
Some studies suggest that cannabis use is associated with suicidal ideation, but no detailed longitudinal study has examined suicide as an outcome.
To examine the association between cannabis use and completed suicide.
A longitudinal study investigated 50 087 men conscripted for Swedish military service, with cannabis use measured non-anonymously at conscription. Suicides during 33 years of follow-up were identified by linkage with the National Cause of Death Register.
There were 600 (1.2% of cohort) suicides or deaths from undetermined causes. Cannabis use was associated with an increased risk of suicide (crude OR for 'ever use' 1.62, 95% CI 1.28-2.07), but this association was eliminated after adjustment for confounding (adjusted OR = 0.88, 95% CI 0.65-1.20).
Although there was a strong association between cannabis use and suicide, this was explained by markers of psychological and behavioural problems. These results suggest that cannabis use is unlikely to have a strong effect on risk of completed suicide, either directly or as a consequence of mental health problems secondary to its use.
一些研究表明，大麻使用与自杀意念有关，但没有详细的纵向研究将自杀作为结局进行研究。
研究大麻使用与自杀完成之间的关联。
一项纵向研究调查了 50087 名应征入伍的瑞典男性军人，大麻使用情况在入伍时进行非匿名测量。通过与国家死因登记处的链接，确定了 33 年随访期间的自杀事件或不明原因死亡。
有 600 人（队列的 1.2%）自杀或死于不明原因。大麻使用与自杀风险增加相关（“曾使用”的粗比值为 1.62，95%置信区间为 1.28-2.07），但在调整混杂因素后，这种关联消失了（调整比值比=0.88，95%置信区间为 0.65-1.20）。
尽管大麻使用与自杀之间存在很强的关联，但这可以用心理和行为问题的标志物来解释。这些结果表明，大麻使用不太可能直接或由于其使用导致的心理健康问题而对自杀完成的风险产生强烈影响。
