Hinckley Jesse D, Mikulich-Gilbertson Susan K, He Jian-Ping, Bhatia Devika, Ellingson Jarrod M, Nguyenkhoa Vu Brian, Ries Merikangas Kathleen, Sakai Joseph T
University of Colorado School of Medicine, Aurora, Colorado.
University of Colorado School of Medicine, Aurora, Colorado; University of Colorado School of Public Health, Aurora, Colorado.
JAACAP Open. 2023 Jun;1(1):24-35. doi: 10.1016/j.jaacop.2023.02.002. Epub 2023 Mar 3.
To investigate the association of cannabis use with major depression and suicidal behavior in adolescence.
Data are from the National Comorbidity Survey-Adolescent Supplement , a nationally representative survey of adolescents aged 13 to 18 years. Weighted logistic regression and ordinal regression analyses of major depression and suicidal behavior outcomes were conducted on cannabis variables, incorporating sociodemographic characteristics.
Adolescents with lifetime cannabis use have 2.07 times higher odds of mild/moderate (adjusted odds ratio [aOR]; 95% ) and 3.32 times higher odds of severe major depressive disorder (MDD; aOR; 95% ). Cannabis use (aOR 6.90, 95% ), mild/moderate MDD (aOR 4.10, 95% ), and severe MDD (aOR 13.97, 95% CI = 7.59, 25.70) were associated with higher odds of suicide attempt. Past 12-month cannabis use (aOR 3.70, 95% CI = 2.16, 6.32), mild/moderate major depressive episodes (MDE) (aOR 7.85, 95% ), and severe MDE (aOR 36.36, 95% ) were associated with higher odds of suicide attempt. The frequency of past 12-month cannabis use was associated with higher odds of suicide attempt and with MDE severity, with higher odds among individuals who use cannabis 3 or more days than among individuals who use cannabis less frequently, suggesting a dose effect. Among cannabis users, older age of onset of cannabis use was associated with lower odds of suicidal behaviors.
Cannabis use is associated with higher odds of depression and depression severity in adolescence. Furthermore, depression and cannabis use are independently associated with higher odds of suicide attempt.
DIVERSITY & INCLUSION STATEMENT: We worked to ensure sex and gender balance in the recruitment of human participants. We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. The author list of this paper includes contributors from the location and/or community where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. We actively worked to promote sex and gender balance in our author group. We actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our author group.
探讨青少年使用大麻与重度抑郁症及自杀行为之间的关联。
数据来自全国共病调查青少年补充调查，这是一项针对13至18岁青少年的全国代表性调查。对大麻使用变量进行加权逻辑回归和有序回归分析，以研究重度抑郁症和自杀行为结果，并纳入社会人口学特征。
终生使用大麻的青少年患轻度/中度重度抑郁症（调整优势比[aOR]；95%置信区间）的几率高2.07倍，患重度重度抑郁症（MDD；aOR；95%置信区间）的几率高3.32倍。使用大麻（aOR 6.90，95%置信区间）、轻度/中度MDD（aOR 4.10，95%置信区间）和重度MDD（aOR 13.97，95%置信区间=7.59，25.70）与自杀未遂几率较高相关。过去12个月内使用大麻（aOR 3.70，95%置信区间=2.16，6.32）、轻度/中度重度抑郁发作（MDE）（aOR 7.85，95%置信区间）和重度MDE（aOR 36.36，95%置信区间）与自杀未遂几率较高相关。过去12个月内使用大麻的频率与自杀未遂几率较高以及MDE严重程度相关，使用大麻3天或以上的个体比使用频率较低的个体自杀未遂几率更高，表明存在剂量效应。在大麻使用者中，开始使用大麻的年龄较大与自杀行为几率较低相关。
青少年使用大麻与抑郁症及抑郁症严重程度几率较高相关。此外，抑郁症和使用大麻与自杀未遂几率较高独立相关。
我们努力确保在招募人类参与者时实现性别平衡。我们努力确保在招募人类参与者时实现种族、民族和/或其他类型的多样性。本文的作者名单包括研究开展地点和/或社区的贡献者，他们参与了数据收集、设计、分析和/或对研究工作的解读。本文的一位或多位作者自我认定为科学领域中一个或多个历史上代表性不足的种族和/或民族群体的成员。我们积极努力促进作者群体中的性别平衡。我们积极努力促进作者群体中纳入科学领域历史上代表性不足的种族和/或民族群体。
