Fujiwara Saeko
Department of Clinical Studies, Radiation Effects Research Foundation, Japan.
Clin Calcium. 2009 Dec;19(12):1730-4.
WHO's FRAX aims to identify bone-fracture high-risk individuals requiring medical intervention by calculating each individual's 10-year probability (%) of bone fracture based on clinical risk factors or clinical risk factors plus bone mineral density (BMD). The risk factors are age, sex, femoral neck mineral density, or body mass index (BMI) if BMD data are unavailable, history of bone fracture, parental history of femoral neck fracture, smoking, consumption of alcohol, use of steroids, rheumatoid arthritis, and secondary osteoporosis. Model with clinical risk factors alone can predict osteoporotic fracture risk as well as the model with BMD and clinical risk factors. FRAX with clinical risk factors alone would be useful to screen those at high risk of fracture in population-based health check-ups.
世界卫生组织的骨折风险评估工具（FRAX）旨在通过基于临床风险因素或临床风险因素加骨密度（BMD）计算每个人10年骨折概率（%），来识别需要医学干预的骨折高危个体。风险因素包括年龄、性别、股骨颈骨密度，若无法获取骨密度数据则为体重指数（BMI）、骨折史、股骨颈骨折家族史、吸烟、饮酒、使用类固醇、类风湿关节炎以及继发性骨质疏松症。仅包含临床风险因素的模型预测骨质疏松性骨折风险的能力与包含骨密度和临床风险因素的模型相当。仅基于临床风险因素的FRAX对于在基于人群的健康检查中筛查骨折高危人群很有用。
