男性骨密度和骨几何形态的年龄比较。

Age comparisons of bone density and geometry in men.

作者信息

Sherk V D, Karabulut M, Bemben M G, Bemben D A

机构信息

Bone Density Research Laboratory, Department of Health and Exercise Science, University of Oklahoma, Norman, Oklahoma 73019, USA.

出版信息

J Musculoskelet Neuronal Interact. 2009 Oct-Dec;9(4):256-62.

PMID:19949283

Abstract

OBJECTIVES

The purposes of this study were to examine tibia bone density and geometry in young and middle aged men, and to explore relationships between pQCT- and DXA-derived body composition variables.

METHODS

Healthy males (18-30 years old, n=31; 50-64 years old, n=37) had their total body areal bone mineral density (aBMD) and body composition measured with Dual Energy X-ray Absorptiometry (DXA). Volumetric bone characteristics, muscle cross-sectional area (MCSA) and fat cross-sectional area (FCSA) of the leg were measured with peripheral Quantitative Computed Tomography (pQCT).

RESULTS

Young men were significantly (p<0.05) lighter and had less fat mass than older men. Total volumetric BMD (vBMD) at 66% of the tibia length was significantly lower (p<0.05) in older men. Bone-free lean body mass values were useful predictors of total and cortical area and content (R(2)=0.338-0.467). MCSA was more predictive of leg BFLBM than total body BFLBM, and those relationships were stronger in older men.

CONCLUSIONS

Differences in tibial bone area and density existed between young and middle-aged men, and relationships between pQCT- and DXA-derived body composition variables were age-dependent.

摘要

目的

本研究旨在检测青年和中年男性的胫骨骨密度及骨几何形态，并探究基于外周定量计算机断层扫描（pQCT）和双能X线吸收法（DXA）得出的身体成分变量之间的关系。

方法

对健康男性（18 - 30岁，n = 31；50 - 64岁，n = 37）采用双能X线吸收法测量其全身面积骨密度（aBMD）和身体成分。采用外周定量计算机断层扫描测量腿部的骨体积特征、肌肉横截面积（MCSA）和脂肪横截面积（FCSA）。

结果

青年男性比老年男性体重显著更轻（p < 0.05）且脂肪量更少。老年男性在胫骨长度66%处的总体积骨密度（vBMD）显著更低（p < 0.05）。去骨瘦体重值是总体积和皮质面积及含量的有效预测指标（R² = 0.338 - 0.467）。MCSA对腿部去骨瘦体重的预测性高于全身去骨瘦体重，且这些关系在老年男性中更强。