衰老与肌肉-骨骼关系
Aging and the muscle-bone relationship.
作者信息
Novotny Susan A, Warren Gordon L, Hamrick Mark W
机构信息
Orthopedic Research Department, Gillette Children's Specialty Healthcare, Saint Paul, Minnesota;
Department of Physical Therapy, Georgia State University, Atlanta, Georgia; and.
出版信息
Physiology (Bethesda). 2015 Jan;30(1):8-16. doi: 10.1152/physiol.00033.2014.
Abstract
Aging-induced declines in muscle size and quality are thought to contribute to catabolic alterations in bone, but changes in bone with age also profoundly alter its response to muscle-derived stimuli. This review provides an overview of some of the alterations that occur in muscle and bone with aging, and discusses the cellular and molecular mechanisms that may impact these age-associated changes.
摘要
衰老导致的肌肉大小和质量下降被认为是造成骨骼分解代谢改变的原因，但随着年龄增长骨骼发生的变化也会深刻改变其对肌肉衍生刺激的反应。本文综述了衰老过程中肌肉和骨骼发生的一些变化，并讨论了可能影响这些与年龄相关变化的细胞和分子机制。
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