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Over the barrier and through the blood: to CNS delivery we go.

作者信息

Foust Kevin D, Kaspar Brian K

出版信息

Cell Cycle. 2009 Dec 15;8(24):4017-8. doi: 10.4161/cc.8.24.10245. Epub 2009 Dec 5.

DOI:10.4161/cc.8.24.10245
PMID:19949299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2911437/
Abstract
摘要

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本文引用的文献

1
The neonatal blood-brain barrier is functionally effective, and immaturity does not explain differential targeting of AAV9.新生儿血脑屏障功能有效，且不成熟并不能解释AAV9的差异靶向性。
Nat Biotechnol. 2009 Sep;27(9):804-5; author reply 805. doi: 10.1038/nbt0909-804.
2
Intravenous administration of self-complementary AAV9 enables transgene delivery to adult motor neurons.静脉注射自我互补的腺相关病毒9型可使转基因传递至成年运动神经元。
Mol Ther. 2009 Jul;17(7):1187-96. doi: 10.1038/mt.2009.71. Epub 2009 Apr 14.
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A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death.小胶质细胞和星形胶质细胞中的Nurr1/CoREST信号通路可保护多巴胺能神经元免受炎症诱导的死亡。
Cell. 2009 Apr 3;137(1):47-59. doi: 10.1016/j.cell.2009.01.038.
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AAV9: a potential blood-brain barrier buster.腺相关病毒9型：一种潜在的血脑屏障突破者。
Mol Ther. 2009 Mar;17(3):403-5. doi: 10.1038/mt.2009.15.
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Crossing the rubicon.破釜沉舟
Nat Biotechnol. 2009 Jan;27(1):42-4. doi: 10.1038/nbt0109-42.
6
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes.血管内注射的腺相关病毒9型（AAV9）优先靶向新生神经元和成年星形胶质细胞。
Nat Biotechnol. 2009 Jan;27(1):59-65. doi: 10.1038/nbt.1515. Epub 2008 Dec 21.
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Delivery of AAV-IGF-1 to the CNS extends survival in ALS mice through modification of aberrant glial cell activity.向中枢神经系统递送腺相关病毒介导的胰岛素样生长因子-1（AAV-IGF-1）可通过改变异常的神经胶质细胞活性来延长肌萎缩侧索硬化症（ALS）小鼠的生存期。
Mol Ther. 2008 Jun;16(6):1056-64. doi: 10.1038/mt.2008.60. Epub 2008 Apr 1.
8
Human brain mapping: hemodynamic response and electrophysiology.人类脑图谱：血液动力学反应与电生理学
Clin Neurophysiol. 2008 Apr;119(4):731-43. doi: 10.1016/j.clinph.2007.10.026. Epub 2008 Jan 9.
9
Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease.神经胶质细胞作为非细胞自主性神经退行性疾病的内在组成部分。
Nat Neurosci. 2007 Nov;10(11):1355-60. doi: 10.1038/nn1988.
10
Dynamics of CNS barriers: evolution, differentiation, and modulation.中枢神经系统屏障的动态变化：进化、分化与调节
Cell Mol Neurobiol. 2005 Feb;25(1):5-23. doi: 10.1007/s10571-004-1374-y.