• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

AAV9: a potential blood-brain barrier buster.

作者信息

Manfredsson Fredric P, Rising Aaron C, Mandel Ronald J

机构信息

Department of Neuroscience, Powell Gene Therapy Center, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, Florida 32610, USA.

出版信息

Mol Ther. 2009 Mar;17(3):403-5. doi: 10.1038/mt.2009.15.

DOI:10.1038/mt.2009.15
PMID:19247366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2835088/
Abstract
摘要

相似文献

1
AAV9: a potential blood-brain barrier buster.腺相关病毒9型:一种潜在的血脑屏障突破者。
Mol Ther. 2009 Mar;17(3):403-5. doi: 10.1038/mt.2009.15.
2
Context-Specific Function of the Engineered Peptide Domain of PHP.B.工程化肽结构域 PHP.B 的上下文特定功能
J Virol. 2021 Sep 27;95(20):e0116421. doi: 10.1128/JVI.01164-21. Epub 2021 Aug 4.
3
Transcellular targeting of fiber- and hexon-modified adenovirus vectors across the brain microvascular endothelial cells in vitro.体外研究纤维和六邻体修饰的腺病毒载体穿过脑微血管内皮细胞的细胞间靶向性。
PLoS One. 2012;7(9):e45977. doi: 10.1371/journal.pone.0045977. Epub 2012 Sep 27.
4
Zebrafish as a model to study drug transporters at the blood-brain barrier.斑马鱼作为血脑屏障药物转运体研究的模型。
Clin Pharmacol Ther. 2012 Nov;92(5):567-70. doi: 10.1038/clpt.2012.168. Epub 2012 Oct 10.
5
Intranasal leptin: blood-brain barrier bypass (BBBB) for obesity?经鼻内给予瘦素:用于治疗肥胖症的血脑屏障绕过法(BBBB)?
Endocrinology. 2006 May;147(5):2086-7. doi: 10.1210/en.2006-0208.
6
The blood-brain barrier: connecting the gut and the brain.血脑屏障:连接肠道与大脑。
Regul Pept. 2008 Aug 7;149(1-3):11-4. doi: 10.1016/j.regpep.2007.08.027. Epub 2008 Apr 7.
7
Physical insights into the blood-brain barrier translocation mechanisms.对血脑屏障转运机制的物理学见解。
Phys Biol. 2017 Jun 6;14(4):041001. doi: 10.1088/1478-3975/aa708a.
8
Modulation of Sialic Acid Dependence Influences the Central Nervous System Transduction Profile of Adeno-associated Viruses.唾液酸依赖性的调节影响腺相关病毒在中枢神经系统中的转导特征。
J Virol. 2019 May 15;93(11). doi: 10.1128/JVI.00332-19. Print 2019 Jun 1.
9
Measurement of phosphorothioate oligodeoxynucleotide antisense transport across the blood-brain barrier.硫代磷酸酯寡脱氧核苷酸反义药物跨血脑屏障转运的测定。
Methods Mol Biol. 2011;789:337-42. doi: 10.1007/978-1-61779-310-3_22.
10
Over the barrier and through the blood: to CNS delivery we go.越过屏障,穿过血液:我们向着中枢神经系统递送前进。
Cell Cycle. 2009 Dec 15;8(24):4017-8. doi: 10.4161/cc.8.24.10245. Epub 2009 Dec 5.

引用本文的文献

1
Gene editing for collagen disorders: current advances and future perspectives.用于胶原蛋白疾病的基因编辑:当前进展与未来展望。
Gene Ther. 2025 Aug 11. doi: 10.1038/s41434-025-00560-7.
2
PET imaging of AAV9 and AAVBR1 trafficking in normal mice.正常小鼠中AAV9和AAVBR1转运的PET成像
Sci Rep. 2025 Feb 4;15(1):4257. doi: 10.1038/s41598-025-86815-0.
3
Determining recombinant AAV capsid extracellular and intracellular biodistribution by dual radioisotope labeling.通过双放射性同位素标记确定重组腺相关病毒衣壳的细胞外和细胞内生物分布。
Mol Ther Methods Clin Dev. 2024 Nov 21;32(4):101373. doi: 10.1016/j.omtm.2024.101373. eCollection 2024 Dec 12.
4
Arming AAV9 with a Single-Chain Fragment Variable Antibody Against PD-1 for Systemic Glioblastoma Therapy.用抗程序性死亡蛋白-1单链可变片段抗体武装AAV9用于系统性胶质母细胞瘤治疗
Mol Neurobiol. 2025 Feb;62(2):2617-2625. doi: 10.1007/s12035-024-04406-y. Epub 2024 Aug 14.
5
Recombinant Adeno-Associated Virus Vectors for Gene Therapy of the Central Nervous System: Delivery Routes and Clinical Aspects.用于中枢神经系统基因治疗的重组腺相关病毒载体:递送途径与临床应用
Biomedicines. 2024 Jul 9;12(7):1523. doi: 10.3390/biomedicines12071523.
6
Treatment of glutaric aciduria type I (GA-I) via intracerebroventricular delivery of GCDH.通过脑室内递送戊二酸脱氢酶治疗I型戊二酸尿症(GA-I)
Fundam Res. 2022 Sep 3;2(6):836-842. doi: 10.1016/j.fmre.2022.08.013. eCollection 2022 Nov.
7
Optimization of systemic AAV9 gene therapy in Niemann-Pick disease type C1 mice.尼曼-匹克病C1型小鼠全身腺相关病毒9型基因治疗的优化
bioRxiv. 2024 Jun 8:2024.06.07.597901. doi: 10.1101/2024.06.07.597901.
8
Mechanistic Evaluation of miRNAs and Their Targeted Genes in the Pathogenesis and Therapeutics of Parkinson's Disease.miRNA及其靶向基因在帕金森病发病机制与治疗中的机制评估
Mol Neurobiol. 2025 Jan;62(1):91-108. doi: 10.1007/s12035-024-04261-x. Epub 2024 Jun 1.
9
Use of adeno-associated viruses for transgenic modulation of microglia structure and function: A review of technical considerations and challenges.腺相关病毒在小胶质细胞结构和功能的转基因调控中的应用:技术考虑因素和挑战综述。
Brain Behav Immun. 2024 May;118:368-379. doi: 10.1016/j.bbi.2024.03.005. Epub 2024 Mar 11.
10
PET imaging of focused-ultrasound enhanced delivery of AAVs into the murine brain.超声聚焦增强 AAV 向小鼠脑内递送的 PET 成像。
Theranostics. 2023 Sep 25;13(15):5151-5169. doi: 10.7150/thno.85549. eCollection 2023.

本文引用的文献

1
Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles.改组腺相关病毒基因组的工程设计与筛选:一种生产靶向生物纳米颗粒的新策略。
Mol Ther. 2008 Jul;16(7):1252-1260. doi: 10.1038/mt.2008.100. Epub 2016 Dec 8.
2
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes.血管内注射的腺相关病毒9型(AAV9)优先靶向新生神经元和成年星形胶质细胞。
Nat Biotechnol. 2009 Jan;27(1):59-65. doi: 10.1038/nbt.1515. Epub 2008 Dec 21.
3
Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis.生长因子与干细胞疗法联合治疗肌萎缩侧索硬化症。
Trends Neurosci. 2008 Apr;31(4):192-8. doi: 10.1016/j.tins.2008.01.006. Epub 2008 Mar 10.
4
The blood-brain barrier in health and chronic neurodegenerative disorders.健康与慢性神经退行性疾病中的血脑屏障
Neuron. 2008 Jan 24;57(2):178-201. doi: 10.1016/j.neuron.2008.01.003.
5
Strategies to advance translational research into brain barriers.推进脑屏障转化研究的策略。
Lancet Neurol. 2008 Jan;7(1):84-96. doi: 10.1016/S1474-4422(07)70326-5.
6
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 7.腺相关病毒7型的生产、纯化及初步X射线晶体学研究
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1073-6. doi: 10.1107/S1744309107060289. Epub 2007 Nov 30.
7
Recombinant adeno-associated virus-mediated global anterograde delivery of glial cell line-derived neurotrophic factor to the spinal cord: comparison of rubrospinal and corticospinal tracts in the rat.重组腺相关病毒介导的胶质细胞源性神经营养因子向脊髓的整体顺行递送:大鼠红核脊髓束和皮质脊髓束的比较
Hum Gene Ther. 2008 Jan;19(1):71-82. doi: 10.1089/hum.2007.104.
8
Neonatal intraperitoneal or intravenous injections of recombinant adeno-associated virus type 8 transduce dorsal root ganglia and lower motor neurons.新生小鼠腹腔内或静脉内注射重组腺相关病毒8型可转导背根神经节和下运动神经元。
Hum Gene Ther. 2008 Jan;19(1):61-70. doi: 10.1089/hum.2007.093.
9
Structure of adeno-associated virus serotype 8, a gene therapy vector.基因治疗载体8型腺相关病毒的结构
J Virol. 2007 Nov;81(22):12260-71. doi: 10.1128/JVI.01304-07. Epub 2007 Aug 29.
10
Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.人类α-突触核蛋白在灵长类动物腹侧中脑过度表达的长期后果。
Brain. 2007 Mar;130(Pt 3):799-815. doi: 10.1093/brain/awl382. Epub 2007 Feb 15.