嗜酸性粒细胞作为变应性上呼吸道疾病的抗原呈递细胞。
Eosinophils as antigen-presenting cells in allergic upper airway disease.
机构信息
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Curr Opin Allergy Clin Immunol. 2010 Feb;10(1):14-9. doi: 10.1097/ACI.0b013e328334f693.
Abstract
PURPOSE OF REVIEW
The recognition of eosinophils as complex immunomodulatory cells has been increasing in recent years. One prominent novel immunomodulatory function of eosinophils is their role as antigen-presenting cells (APCs). This review will examine the evidence that has enhanced the understanding of eosinophils as APCs in the context of allergic inflammation, with a focus on data applicable to allergic upper airway disease.
RECENT FINDINGS
Recent studies expand on prior findings that eosinophils can express major histocompatibility complex class II and costimulatory molecules. Eosinophils have also been found to traffic to regional lymph nodes and act as professional APCs in various experimental settings.
SUMMARY
Accumulating evidence of the ability of eosinophils to act as APCs suggests that eosinophils may have more complex immunomodulatory roles in allergic upper airway disease than previously appreciated.
摘要
目的综述
近年来，人们越来越认识到嗜酸性粒细胞是一种具有复杂免疫调节功能的细胞。嗜酸性粒细胞的一个突出的新型免疫调节功能是作为抗原呈递细胞 (APC)。本文综述了嗜酸性粒细胞作为 APC 在过敏炎症中的作用的相关证据，重点是适用于过敏性上呼吸道疾病的数据。
最近的发现
最近的研究扩展了先前的发现，即嗜酸性粒细胞可以表达主要组织相容性复合体 II 类和共刺激分子。研究还发现，嗜酸性粒细胞可以迁移到局部淋巴结，并在各种实验环境中充当专业的 APC。
总结
越来越多的证据表明嗜酸性粒细胞具有作为 APC 的能力，这表明嗜酸性粒细胞在过敏性上呼吸道疾病中的免疫调节作用比以前认为的更为复杂。
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