Krenzelok E P, Lush R M
Pittsburgh Poison Center, Children's Hospital of Pittsburgh, PA.
Am J Emerg Med. 1991 Mar;9(2):144-6. doi: 10.1016/0735-6757(91)90176-k.
Commercial aqueous activated charcoal (AC) products may sit in emergency departments, pharmacies, and homes for prolonged periods resulting in the inability to resuspend the AC for patient administration. The potential risk to the patient from not receiving an adequate amount of AC, especially when AC may be the sole means of gastric decontamination, is obvious. To simulate this potential problem, samples of five different aqueous AC products (ActaChar, Actidose, InstaChar, LiquiChar, and SuperChar) were placed into storage for periods of 3 and 12 months. At the end of each study period, samples were agitated and the effluent and container residue were collected, oven-dried, and weighed. With the exception of Actidose, all products retained substantial amounts of AC in the container at both time intervals. These data stress the negative impact of dormant storage on the resuspendability of aqueous activated charcoal products. Furthermore, they suggest the importance of thorough container agitation and rinsing to insure that the patient receives sufficient AC. This is especially important when AC is the sole means of decontamination.
市售的水性活性炭（AC）产品可能会在急诊科、药房和家庭中长时间存放，导致无法将活性炭重新悬浮以供患者服用。患者因未摄入足量活性炭而面临的潜在风险显而易见，尤其是在活性炭可能是胃去污的唯一手段时。为模拟这一潜在问题，将五种不同的水性活性炭产品（ActaChar、Actidose、InstaChar、LiquiChar和SuperChar）的样本存放3个月和12个月。在每个研究阶段结束时，搅拌样本，收集流出物和容器残渣，烘干并称重。除了Actidose之外，所有产品在两个时间间隔内均在容器中保留了大量活性炭。这些数据强调了长期储存对水性活性炭产品再悬浮性的负面影响。此外，这些数据还表明充分搅拌容器和冲洗的重要性，以确保患者摄入足够的活性炭。当活性炭是唯一的去污手段时，这一点尤为重要。
