Amir D
A.R.O., Volcani Center, Bet Dagan, Israel.
Mol Reprod Dev. 1991 Jan;28(1):99-109. doi: 10.1002/mrd.1080280116.
The spermicidal effect of ethylene dibromide (EDB) in bulls and rams is reviewed. Following oral or parenteral administration EDB was found to cause, by its alkylating effect in the testes of treated bulls and rams, lysis of the chromatin of the elongating spermatids during the time of somatin histones replacement by the sperm protamines. However, while in the bulls the abnormal spermatozoa issued from the affected spermatids were also collected in the ejaculates, this was not the case with treated rams. In the latter animals the abnormal spermatids seem to be phagocytized in the epididymis before their arrival in the ejaculate. In addition, whereas the alkylating effect of EDB occurred also in the upper parts of the epididymis of the bulls, causing tail and acrosome defects to the spermatozoa, in the rams such an effect seems to occur all along the epididymal duct. These differences between bulls and rams in the sites of the genital tract where the drug takes effect, and in the mechanism of this effect, reveal probable differences in the physiology of the reproductive tract between these species.
综述了二溴乙烷（EDB）对公牛和公羊的杀精作用。经口服或肠胃外给药后，发现EDB通过对接受治疗的公牛和公羊睾丸的烷基化作用，在精子鱼精蛋白取代体细胞组蛋白期间，导致伸长型精子细胞的染色质溶解。然而，虽然在公牛中，受影响精子细胞产生的异常精子也会出现在射精中，但经治疗的公羊却并非如此。在后者中，异常精子细胞似乎在到达射精部位之前就已在附睾中被吞噬。此外，虽然EDB的烷基化作用也发生在公牛附睾的上部，导致精子出现尾部和顶体缺陷，但在公羊中，这种作用似乎沿附睾管全程发生。公牛和公羊在药物起作用的生殖道部位以及这种作用机制上的这些差异，揭示了这些物种在生殖道生理学方面可能存在的差异。
