腺苷与纤维化。
Adenosine in fibrosis.
机构信息
Clinical and Translational Science Institute, NYU School of Medicine, 550 First Ave., New York, NY 10016, USA.
出版信息
Mod Rheumatol. 2010 Apr;20(2):114-22. doi: 10.1007/s10165-009-0251-4. Epub 2009 Dec 1.
Abstract
Adenosine is an endogenous autocoid that regulates a multitude of bodily functions. Its anti-inflammatory actions are well known to rheumatologists since it mediates many of the anti-inflammatory effects of a number of antirheumatic drugs such as methotrexate. However, inflammatory and tissue regenerative responses are intricately linked, with wound healing being a prime example. It has only recently been appreciated that adenosine has a key role in tissue regenerative and fibrotic processes. An understanding of these processes may shed new light on potential therapeutic options in diseases such as scleroderma where tissue fibrosis features prominently.
摘要
腺苷是一种内源性自体活性物质，可调节多种身体功能。风湿学家熟知其抗炎作用，因为它介导了许多抗风湿药物（如甲氨蝶呤）的许多抗炎作用。然而，炎症和组织再生反应是错综复杂地联系在一起的，伤口愈合就是一个很好的例子。最近人们才意识到，腺苷在组织再生和纤维化过程中起着关键作用。对这些过程的了解可能会为硬皮病等疾病的潜在治疗选择提供新的思路，因为这些疾病的特征是组织纤维化。
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