Robert M. Berne Cardiovascular Research Center, Division of Cardiovascular Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 22903, USA.
Molecules. 2023 Aug 9;28(16):5980. doi: 10.3390/molecules28165980.
Cannabidiol (CBD) is the primary non-psychoactive chemical from Cannabis Sativa, a plant used for centuries for both recreational and medicinal purposes. CBD lacks the psychotropic effects of Δ9-tetrahydrocannabinol (Δ9-THC) and has shown great therapeutic potential. CBD exerts a wide spectrum of effects at a molecular, cellular, and organ level, affecting inflammation, oxidative damage, cell survival, pain, vasodilation, and excitability, among others, modifying many physiological and pathophysiological processes. There is evidence that CBD may be effective in treating several human disorders, like anxiety, chronic pain, psychiatric pathologies, cardiovascular diseases, and even cancer. Multiple cellular and pre-clinical studies using animal models of disease and several human trials have shown that CBD has an overall safe profile. In this review article, we summarize the pharmacokinetics data, the putative mechanisms of action of CBD, and the physiological effects reported in pre-clinical studies to give a comprehensive list of the findings and major effects attributed to this compound.
大麻二酚（CBD）是大麻植物中的主要非精神活性化学物质，该植物被用于娱乐和药用已有数百年的历史。CBD 缺乏 Δ9-四氢大麻酚（Δ9-THC）的精神活性作用，并且具有巨大的治疗潜力。CBD 在分子、细胞和器官水平上发挥广泛的作用，影响炎症、氧化损伤、细胞存活、疼痛、血管扩张和兴奋等，从而改变许多生理和病理生理过程。有证据表明，CBD 可能对治疗多种人类疾病有效，如焦虑、慢性疼痛、精神病理学、心血管疾病，甚至癌症。多项使用疾病动物模型的细胞和临床前研究以及多项人体试验表明，CBD 的整体安全性良好。在这篇综述文章中，我们总结了 CBD 的药代动力学数据、推测的作用机制以及临床前研究中报告的生理效应，列出了与该化合物相关的发现和主要作用的综合清单。
