Fehr Peter, Nygren Karl-Gösta, De Geyter Christian
Präsident der FIVNAT-Kommission, Schaffhausen.
Ther Umsch. 2009 Dec;66(12):825-9. doi: 10.1024/0040-5930.66.12.825.
Currently, there is a rising trend to consider a multiple delivery as a genuine complication of assisted reproduction, which can be prevented by the replacement of one single, selected embryo. Particularly previously infertile women due to their poor reproductive function are at risk of complications during gestation leading to premature delivery. Cerebral palsy is the most common consequence of multiple gestation and a significant cause of disabling among the offspring. Particularly Swedish specialists in reproductive medicine have been at the forefront of the development of single embryo transfer (denominated SET), which has become the main therapeutic strategy in IVF since 2004. In Sweden, approximately 70 % of all treatment cycles with assisted reproduction are now being performed with SET. Despite the transfer of fewer embryos per cycle, acceptable pregnancy rates are being achieved thereby reducing the multiple delivery rate to approximately 5 %. In Switzerland, however, legal restrictions ban the selection of embryos, so that all available embryos (not more than three) are still being transferred.
目前，将多胎分娩视为辅助生殖的一种真正并发症的趋势正在上升，而通过移植单个选定的胚胎可以预防这种情况。特别是以前因生殖功能差而不孕的女性，在孕期有发生并发症导致早产的风险。脑瘫是多胎妊娠最常见的后果，也是后代致残的一个重要原因。尤其是瑞典的生殖医学专家一直处于单胚胎移植（简称SET）发展的前沿，自2004年以来，单胚胎移植已成为体外受精的主要治疗策略。在瑞典，目前约70%的辅助生殖治疗周期采用单胚胎移植。尽管每个周期移植的胚胎数量减少了，但仍能达到可接受的妊娠率，从而将多胎分娩率降低到约5%。然而，在瑞士，法律限制禁止选择胚胎，因此所有可用的胚胎（不超过三个）仍被移植。
