混合性冷球蛋白血症中促炎细胞因子白细胞介素-1β、白细胞介素-6和肿瘤坏死因子α的血清水平。
Serum levels of proinflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor alpha in mixed cryoglobulinemia.
作者信息
Antonelli Alessandro, Ferri Clodoveo, Ferrari Silvia Martina, Ghiri Emiliano, Goglia Fernando, Pampana Alessandro, Bruschi Fabrizio, Fallahi Poupak
机构信息
Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy.
出版信息
Arthritis Rheum. 2009 Dec;60(12):3841-7. doi: 10.1002/art.25003.
OBJECTIVE
No single previous study has evaluated serum levels of the proinflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor alpha (TNFalpha) in patients with hepatitis C virus-associated mixed cryoglobulinemia (HCV-MC). This study was undertaken to evaluate serum levels of these cytokines in patients with HCV-MC.
METHODS
Serum IL-1beta, IL-6, and TNFalpha were assayed in 43 patients with HCV-MC, in 43 sex- and age-matched patients with chronic HCV without cryoglobulinemia, and in 43 sex- and age-matched controls.
RESULTS
HCV-MC patients showed significantly higher mean IL-1beta, IL-6, and TNFalpha levels than did the controls (P<0.01) or the HCV patients (P<or=0.04). Serum levels of IL-6 and TNFalpha were significantly higher in HCV patients than in controls (P<0.05).
CONCLUSION
Our findings demonstrate elevated serum levels of IL-1beta, IL-6, and TNFalpha in patients with HCV-MC. If the importance of IL-1beta and IL-6 in the pathogenesis of MC is confirmed, these results will open the way for the evaluation of new therapies for MC.
目的
此前尚无单一研究评估丙型肝炎病毒相关混合性冷球蛋白血症（HCV-MC）患者血清中促炎细胞因子白细胞介素-1β（IL-1β）、IL-6和肿瘤坏死因子α（TNFα）的水平。本研究旨在评估HCV-MC患者血清中这些细胞因子的水平。
方法
对43例HCV-MC患者、43例年龄和性别匹配的无冷球蛋白血症的慢性丙型肝炎患者以及43例年龄和性别匹配的对照者检测血清IL-1β、IL-6和TNFα。
结果
HCV-MC患者的平均IL-1β、IL-6和TNFα水平显著高于对照组（P<0.01）或丙型肝炎患者（P≤0.04）。丙型肝炎患者的血清IL-6和TNFα水平显著高于对照组（P<0.05）。
结论
我们的研究结果表明HCV-MC患者血清中IL-1β、IL-6和TNFα水平升高。如果IL-1β和IL-6在混合性冷球蛋白血症发病机制中的重要性得到证实，这些结果将为评估混合性冷球蛋白血症的新疗法开辟道路。
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